ArticleChemical science2024
Access to distal biaxial atropisomers by iridium catalyzed asymmetric C-H alkylation.
Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Enantioselective Iridium-Catalyzed C-H Bond Alkylation for the Synthesis of N-N Atropisomeric Phosphines.Journal of the American Chemical Society · 2026Article
- Recent advances in the stereoselective synthesis of distal biaxially chiral molecules.Beilstein journal of organic chemistry · 2026Review
- Visible-light-mediated site-selective C(spChemical science · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Distal biaxial atropisomers are typical structures in chiral catalysts and ligands and offer a wide variety of applications in biology and materials technology, but the development of efficient synthesis of these valuable scaffolds is still in great demand. Herein, we describe a highly efficient iridium catalyzed asymmetric C-H alkylation reaction that provides a range of new distal biaxial atropisomers with excellent yields (up to 99%) and stereoselectivity (up to 99% ee and essentially one isomer). Based on this unprecedented strategy, a polycyclic skeleton with five successive chiral centers as well as C-C and C-N (or N-N) two distal chiral axes was created successfully in mild circumstances. In addition, the optically pure products bearing fluorophores show circular polarized luminescence (CPL) properties, being potential candidate materials for CPL applications.
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Registered trials
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