Evidence map›Paper›PMID 39183814›Full record

ArticleOpen forum infectious diseases2024

Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata.

Grace X Li, Komal Gopchandani, Noah Brazer, Ashley Tippett, Chris Choi, Hui-Mien Hsiao, Miriam Oseguera, Abiodun Foresythe, Sanchita Bhattacharya, Venice Servellita and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Grace X LiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Komal GopchandaniDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Noah BrazerDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Ashley TippettDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Chris ChoiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Hui-Mien HsiaoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Miriam OsegueraDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Abiodun ForesytheDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Sanchita BhattacharyaBakar Computational Health Sciences Institute, University of California, San Francisco, CA, USA.
Venice ServellitaDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Alicia Sotomayor GonzalezDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Jennifer K SpinlerDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.
Mark D GonzalezDepartment of Pathology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Dalia GulickGeorgia Clinical & Translational Science Alliance, Emory University School of Medicine, Atlanta, GA, USA.
Colleen KraftDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-1757-8477
Vyjayanti KasinathanDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Yun F Wayne WangDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Jennifer Dien BardDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-0524-9473
Pei Ying ChenDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jessica Flores-VazquezDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Audrey R Odom JohnDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Paul J PlanetDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sridevi DevarajDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.
Ananth V AnnapragadaDepartment of Radiology, Baylor College of Medicine, Houston, TX, USA.
Ruth Ann LunaDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.
Charles Y ChiuDepartment of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco, San Francisco, CA, USA.
Christina A RostadDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0001-8439-0592

Funding

Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19R33HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2023 to 2023
$3.2M
Uncovering associations of variant infection with COVID-19 disease severity in childrenR61HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2021 to 2022
$3.2M
Diagnosis of MIS-C in febrile childrenR33HD105594 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSIRI, HAMID, ODOM JOHN, AUDREY RAGAN · 2023 to 2023
$2.9M
NICHD NIH HHS R33 HD105594NICHD NIH HHS R33 HD105618NICHD NIH HHS R61 HD105618
6 · The paper itself

Abstract

Background: Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults. Methods: This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVID-19 from March 2020 to May 2023 across age strata at 5 US sites participating in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence consortium. Eligible patients had an upper respiratory swab that tested positive for severe acute respiratory syndrome coronavirus 2 by nucleic acid amplification. Adjusted odds ratios (aOR) of clinical outcomes were determined for children versus adults, for pediatric age strata compared to adolescents (12-17 years), and for adult age strata compared to young adults (22-49 years). Results: Of 9101 patients in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence cohort, 1560 were hospitalized for COVID-19 as the primary reason. Compared to adults (22-105 years, n = 675), children (0-21 years, n = 885) were less commonly vaccinated (14.3% vs 34.5%), more commonly infected with the Omicron variant (49.5% vs 26.1%) and had fewer comorbidities ( Conclusions: Clinical outcomes of COVID-19 differed across pediatric and adult age strata. Adolescents experienced the most severe disease among children, whereas adults 50-64 years experienced the most severe disease among adults.

Indexed as

adultschildrencoronaviruscoronavirus disease 2019SARS-CoV-2

Identifiers

PMID39183814
PMCPMC11342389

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.