Evidence map›Paper›PMID 39183793›Full record

ArticleJournal of polymer science (2020)2024

Lens epithelial cell response to polymer stiffness and polymer chemistry.

Hamid Hamedi, Spencer W Green, Raima Puri, Richard Luo, Michael Lee, Jian Liu, Hanna Cho, Derek J Hansford, Heather L Chandler, Katelyn E Swindle-Reilly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of polymer science (2020), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamid HamediDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Spencer W GreenDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Raima PuriDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Richard LuoDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Michael LeeDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio, USA.
Jian LiuDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio, USA.
Hanna ChoDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio, USA.
Derek J HansfordDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Heather L ChandlerCollege of Optometry, Ohio State University, Columbus, Ohio, USA.
Katelyn E Swindle-ReillyDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.

Funding

Lens Epithelial Cell Response to Biomaterial InterfacesR21EY032226 · NEI · OHIO STATE UNIVERSITY · PI SWINDLE-REILLY, KATELYN E · 2022 to 2023
$404k
NEI NIH HHS R21 EY032226
6 · The paper itself

Abstract

Posterior capsule opacification (PCO) is the most common complication of cataract surgery, and intraocular lens (IOL) implantation is the standard of care for cataract patients. Induction of post-operative epithelial-mesenchymal transition (EMT) in residual lens epithelial cells (LEC) is the main mechanism by which PCO forms. Previous studies have shown that IOLs made with different materials have varying incidence of PCO. The aim of this paper was to study the interactions between human (h)LEC and polymer substrates. Polymers and copolymers of 2-hydroxyethyl methacrylate (HEMA) and 3-methacryloxypropyl tris (trimethylsiloxy) silane (TRIS) were synthesized and evaluated due to the clinical use of these materials as ocular biomaterials and implants. The chemical properties of the polymer surfaces were evaluated by contact angle, and polymer stiffness and roughness were measured using atomic force microscopy.

Indexed as

epithelial-mesenchymal transitionlens epithelial cellpolymer surfaceposterior capsule opacificationstiffness

Identifiers

PMID39183793
PMCPMC11340881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.