ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Associations between accelerometer-derived sedentary behavior and physical activity with white matter hyperintensities in middle-aged to older adults.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of physical activity bout duration and fragmentation with future dementia, depression, and anxiety: a multi-modal UK Biobank study.Translational psychiatry · 2026Article
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Associations between accelerometer-derived sedentary behavior and physical activity with white matter hyperintensities in middle-aged to older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Associations between lifestyle, genetic risk for Alzheimer's disease, and longitudinal brain atrophy in the UK Biobank (Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors.
Funding
Abstract
introductionWe examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.
methodsWe used data from the UK Biobank (
resultsBoth MVPA and SB were associated with WMH volumes (β DISCUSSION: While this study cannot establish causality, the results highlight the potential importance of considering both MVPA and SB in strategies aimed at reducing the accumulation of WMH volumes in middle-aged to older adults. Highlights: SB is associated with greater WMH volumes and MVPA is associated with lower WMH volumes.Relationships between SB and WMH are strongest at low levels of MVPA.Associations between MVPA and WMH are strongest at high levels of SB.Considering both SB and MVPA may be effective strategies for reducing WMHs.
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