Evidence map›Paper›PMID 39183729›Full record

ArticleTetrahedron letters2024

Synthesis of 3,3-Disubstituted Allyl Isoindolinones via Pd-Catalyzed Decarboxylative Allylic Alkylation.

Mario Alvarado, Marisa Loo, Hanna Adler, Caroline Arnall, Katharine Amsden, Gisela Martinez, Raul Navarro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mario AlvaradoDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Marisa LooDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Hanna AdlerDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Caroline ArnallDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Katharine AmsdenDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Gisela MartinezDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Raul NavarroDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.

Funding

Regiodivergent Palladium-Catalyzed Decarboxylative Coupling of Stabilized Benzylic NucleophilesR15GM151690 · NIGMS · OCCIDENTAL COLLEGE · PI NAVARRO, RAUL · 2023 to 2023
$342k
NIGMS NIH HHS R15 GM151690
6 · The paper itself

Abstract

Herein, we report a mild palladium-catalyzed decarboxylative allylic alkylation of allyl ester-substituted isoindolinone substrates to afford a variety of 3,3-disubstituted isoindolinone derivatives. The decarboxylative coupling reaction tolerates a range of functional groups, including ketones and alkenyl halides, and does not require protection of the isoindolinone nitrogen. Additionally, the reaction was found to proceed in near-quantitative yield for most substrates evaluated. Based on the isolation of competing cyclopropane and protonation products, a reaction mechanism is proposed.

Indexed as

allylationdecarboxylativeisoindolinonespalladium-catalyzed

Identifiers

PMID39183729
PMCPMC11343487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.