Evidence map›Paper›PMID 39183641›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Exploring the utility of ultrasound to assess disuse atrophy in different muscles of the lower leg.

Edward J Hardy, Joseph J Bass, Thomas B Inns, Mathew Piasecki, Jessica Piasecki, Craig Sale, Robert H Morris, Jonathan N Lund, Ken Smith, Daniel J Wilkinson and 2 more

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Edward J HardyCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Joseph J BassCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Thomas B InnsCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Mathew PiaseckiCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Jessica PiaseckiSchool of Science and Technology, Nottingham Trent University, Nottingham, UK.
Craig SaleSchool of Science and Technology, Nottingham Trent University, Nottingham, UK.
Robert H MorrisSchool of Science and Technology, Nottingham Trent University, Nottingham, UK.
Jonathan N LundCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Ken SmithCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Daniel J WilkinsonCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Philip J AthertonCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.
Bethan E PhillipsCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR), and Nottingham NIHR Biomedical Research Centre, University of Nottingham, School of Medicine, Derby, UK.ORCID 0000-0002-1430-1870

Funding

BBSRC grant BB/R010358/1Medical Research Council MR/X005240/1Medical Research Council (MRC), United Kingdom MR/P021220/1Medical Research Council (MRC), United Kingdom MR/X005240/1National Institute for Health Research, United KingdomNottingham Biomedical Research Centre
6 · The paper itself

Abstract

backgroundSkeletal muscle is a highly plastic tissue crucial for many functions associated with whole-body health across the life course. Magnetic resonance imaging (MRI) is the current gold standard for measuring skeletal muscle size. However, MRI is expensive, and access to facilities is often limited. B-mode ultrasonography (U/S) has been proposed as a potential alternative to MRI for the assessment of muscle size. However, to date, no work has explored the utility of U/S to assess disuse muscle atrophy (DMA) across muscles with different atrophy susceptibility profiles, an omission which may limit the clinical application of previous work.

methodsTo address this significant knowledge gap, 10 young men (22 ±  years, 24.1 ± 2.3 kg/m

resultsWith both muscles combined, there were good correlations between each U/S and MRI measure, both before (e.g., CSA

conclusionsBoth MT

Indexed as

LegMuscle, SkeletalMuscular Disorders, AtrophicUltrasonographyAdultHumansMagnetic Resonance ImagingMaleYoung AdultDisuseImagingMRIMuscleUltrasound

Identifiers

PMID39183641
PMCPMC11634512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.