Evidence map›Paper›PMID 39183278›Full record

ArticleBMC biology2024

Phospho-code of a conserved transcriptional factor underpins fungal virulence.

Jiyun Yang, Bing Li, Yu-Ting Pan, Ping Wang, Mei-Ling Sun, Ki-Tae Kim, Hui Sun, Jian-Ren Ye, Zhen Jiao, Yong-Hwan Lee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiyun Yang *Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.ORCID http://orcid.org/0000-0003-4629-5978
Bing Li *School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China. 006805@yzu.edu.cn.
Yu-Ting PanCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Ping WangCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Mei-Ling SunCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Ki-Tae KimDepartment of Agricultural Life Science, Sunchon National University, Suncheon, 57922, Korea.
Hui SunCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Jian-Ren YeCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Zhen JiaoSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Yong-Hwan LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
Lin HuangCo-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China. lhuang@njfu.edu.cn.

Funding

Chongqing Postdoctoral Science Foundation 2022M712886National Key R & D Program of China 2017YFD0600102Priority Academic Program Development of Jiangsu Higher Education Institutions PAPDthe Foundation of Key Technology Research Project of Henan Province 222102110031the National Science Foundation of China 32101530; 31870631;32371888
6 · The paper itself

Abstract

backgroundCell wall integrity (CWI) is crucial for fungal growth, pathogenesis, and adaptation to extracellular environments. Calcofluor white (CFW) is a cell wall perturbant that inhibits fungal growth, yet little is known about how phytopathogenic fungi respond to the CFW-induced stress.

resultsIn this study, we unveiled a significant discovery that CFW triggered the translocation of the transcription factor CgCrzA from the cytoplasm to the nucleus in Colletotrichum gloeosporioides. This translocation was regulated by an interacting protein, CgMkk1, a mitogen-activated protein kinase involved in the CWI pathway. Further analysis revealed that CgMkk1 facilitated nuclear translocation by phosphorylating CgCrzA at the Ser280 residue. Using chromatin immunoprecipitation sequencing, we identified two downstream targets of CgCrzA, namely CgCHS5 and CgCHS6, which are critical for growth, cell wall integrity, and pathogenicity as chitin synthase genes.

conclusionsThese findings provide a novel insight into the regulatory mechanism of CgMkk1-CgCrzA-CgChs5/6, which enables response of the cell wall inhibitor CFW and facilitates infectious growth for C. gloeosporioides.

Indexed as

ColletotrichumFungal ProteinsTranscription FactorsCell WallGene Expression Regulation, FungalPhosphorylationVirulenceFungal ProteinsTranscription FactorsCalcofluor white CFWCell wall integrityChitin synthasesMitogen-activated protein kinase CgMkk1PathogenicityPhosphorylationTranscription factor CgCrzA

Identifiers

PMID39183278
PMCPMC11346053

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.