Evidence map›Paper›PMID 39183230›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2024

Investigate the relationship between pulsed field ablation parameters and ablation outcomes.

Lianru Zang, Kaihao Gu, Tuo Zhou, Peng Si, Xingkai Ji, Hao Zhang, Shengjie Yan, Xiaomei Wu

Abstract read
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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lianru ZangDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China.
Kaihao GuDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China.
Tuo ZhouCardiac Electrophysiology R&D Center, APT Medical Inc., Shenzhen, 518057, China.
Peng SiCardiac Electrophysiology R&D Center, APT Medical Inc., Shenzhen, 518057, China.
Xingkai JiDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China.
Hao ZhangDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China.
Shengjie YanDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China. sjyan@fudan.edu.cn.
Xiaomei WuDepartment of Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200438, China. xiaomeiwu@fudan.edu.cn.

Funding

National Key Research and Development Program of China 2021YFC2400203National Key Research and Development Program of China 2022YFC2404904Science and Technology Commission of Shanghai Municipality 21S31906900Science and Technology Commission of Shanghai Municipality 23S31905300Science and Technology Commission of Shanghai Municipality GYQJ-2018-2-05
6 · The paper itself

Abstract

backgroundPulsed field ablation (PFA) is an emerging non-thermal ablation method. The primary challenge is the control of multiple parameters in PFA, as the interplay of these parameters remains unclear in terms of ensuring effective and safe tissue ablation. PURPOSE: This study employs the response surface method (RSM) to explore the interactions between various PFA parameters and ablation outcomes, and seeks to enhance the efficacy and safety of PFA.

methodsIn vivo experiments were conducted using rabbit liver for varying PFA parameters: pulse amplitude (PA), pulse interval (PI), number of pulse trains (NT), and number of pulses in a pulse train (NP). Ablation outcomes assessed included three ablation sizes, surface temperature, and muscle contraction strength. Additionally, histological analysis was performed on the ablated tissue. We analyzed the relationship between PFA parameters and ablation outcomes, and results were then compared with those from a simulation using an electric-thermal coupling PFA finite element model.

resultsA linear relationship between ablation outcomes and PFA parameters was established. PA and NT exhibited extremely significant (P < 0.0001) and significant effects (P < 0.05) on all ablation outcomes, respectively. NP showed an extremely significant impact (P < 0.0001) on surface temperature and muscle contraction strength, while PI significantly influenced (P < 0.05) muscle contraction strength alone. Histological analysis revealed that PFA produces controlled, well-defined areas of liver tissue necrosis. Surface temperature results from simulations and experiments were highly consistent (R

conclusionsThis study clarifies the relationship between various PFA parameters and ablation outcomes, and aims to improve the efficacy and safety of PFA.

Indexed as

Finite element analysisIn vivo experimentPulsed field ablationResponse surface method

Identifiers

PMID39183230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.