Trial reportKorean journal of anesthesiology2024
Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery.
Trial report in Korean journal of anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of opioid-free anesthetic on postoperative complication following gynecological surgery: a meta-analysis.Revista da Escola de Enfermagem da U S P · 2025Pooled it
- Effect of preoperative ultrasound-guided stellate ganglion block on pain thresholds and postoperative nausea and vomiting in gynecological laparoscopy: a randomised clinical trial.BMC anesthesiology · 2026Trial
- Effective Dose of Oliceridine for Inhibiting Hemodynamic Elevation Induced by Tracheal Intubation: An Up-and-Down Sequential Trial.Drug design, development and therapy · 2025Trial
- The Effects of Low-Dose Esketamine Combined with Paravertebral Block on Postoperative Hyperalgesia and Enhanced Recovery in Non-Intubated Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Safety and Analgesic Effectiveness of Adding Butorphanol to Multimodal Intravenous Patient-Controlled Analgesia After Gynecologic Surgery: A Retrospective Cohort Study.Pain and therapy · 2026Article
- Study on anaesthetic agent propofol and sevoflurane as maintenance agent along with anti-emetic drug ondansetron in reducing post operative nausea and vomiting in high-risk patients.BMC anesthesiology · 2026Observational
- Regional Blocks in the Era of the Opioid Crisis: Evaluating Their Opioid-Sparing Effect.Cureus · 2026Review
- Investigation of the incidence of early and delayed postoperative nausea and vomiting (PONV) in different surgical specialties.Scientific reports · 2026Observational
- Combined epidural-general anesthesia reduces opioid use and improves recovery after laparoscopic hysterectomy: a retrospective cohort study.Perioperative medicine (London, England) · 2026Article
- Postoperative nausea and vomiting: current concepts, management strategies, and future perspectives.Frontiers in pharmacology · 2026Review
- Article
- Recovery Profiles and Well-Being Outcomes in Patients Undergoing Various Anaesthesia Techniques: A Systematic Review.Health science reports · 2025Review
- Comparison of Postoperative Analgesic Profiles Between Transversus Abdominis Plane Block and Local Wound Infiltration in Living Donor Kidney Transplantation Recipients: A Propensity Score-Matched Analysis.Life (Basel, Switzerland) · 2025Article
- Global research frontiers and thematic trends in opioid-free anesthesia over the past 20 years: a bibliometric analysis.Frontiers in pharmacology · 2025Review
- Clinical trial effects of acupuncture combined with different general anesthesia on postoperative nausea and vomiting and early recovery after thyroidectomy with intra-operative neuromonitoring: a randomized controlled trial.Frontiers in medicine · 2025Article
- Achieving relief from nausea and vomiting: from intraoperative to postoperative management.Korean journal of anesthesiology · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIn this study, we aimed to investigate whether opioid-sparing anesthesia (OSA) reduces postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecological surgery.
methodsAdult patients undergoing elective laparoscopic gynecological surgery were randomly assigned to either the opioid-using anesthesia (OUA) or the OSA groups. In the OUA group, remifentanil was administered as an opioid during general anesthesia. In the OSA group, apart from a single dose of 5 μg/kg of alfentanil for tracheal intubation, no other opioids were used. In both groups, a multimodal intravenous non-opioid analgesic regimen was used preferentially in the post-anesthesia care unit (PACU). The primary outcome was the incidence of PONV, assessed by symptoms until the postoperative day 1.
resultsA total of 120 patients were included in this study. The incidence of nausea in the PACU was significantly lower in the OSA group compared to in the OUA group (31.7% in the OSA group vs. 51.7% in the OUA group, P = 0.026). Pain scores and the incidence of opioid analgesic administration were lower in the OSA group during PACU stay, resulting in a significantly lower number of patients requiring rescue opioid analgesics (3.3% vs. 18.3%, P = 0.008). There were no significant differences in intraoperative vital signs, hemodynamic interventions, or duration of PACU and hospital stay between the two groups.
conclusionsOSA significantly reduced postoperative nausea, pain scores, and the need for rescue analgesics in the PACU without increasing hemodynamic instability in patients undergoing laparoscopic gynecological surgery.
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