Evidence map›Paper›PMID 39183056›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024

A novel bakuchiol aminoguanidine derivative induces apoptosis in human triple-negative breast cancer cells.

Zhenhai Zhang, Jing Zhu, Jian'an Wang, Jie Chen, Yingying Pang, Chengzhu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhenhai ZhangDepartment of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China. 012012030@bbmc.edu.cn.
Jing ZhuSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
Jian'an WangSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
Jie ChenSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
Yingying PangDepartment of Respiratory Disease, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China. 1020207@bbmc.edu.cn.
Chengzhu WuSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, Anhui Province, China. wuchengzhu0611@bbmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo synthesize new bakuchiol aminoguanidine derivatives and test their effect on viability and apoptosis of human triple-negative breast cancer (TNBC) cells.

methodsTwo bakuchiol derivatives 1 and 2 were obtained by formylation and Shiff base reaction of bakuchol. The structures of derivatives 1 and 2 were identified by

resultsBased on spectroscopic analysis, a new bakuchiol schiff base derivative was elucidated as 2-{(

conclusionsThe novel bakuchiol aminoguanidine derivative (derivative 2) is capable of inducing apoptosis in MDA-MB-231 cells, but has low toxicity to normal liver cells, suggesting that it may be used as a lead compound for an anti-TNBC agent.

Indexed as

ApoptosisGuanidinesPhenolsReactive Oxygen SpeciesTriple Negative Breast NeoplasmsCell Line, TumorCell SurvivalFemaleHumansbakuchiolGuanidinesPhenolspimagedineReactive Oxygen SpeciesAminoguanidineApoptosisBakuchiolMitochondrial functionTriple-negative breast cancer

Identifiers

PMID39183056
PMCPMC11375495

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.