Evidence map›Paper›PMID 39182706›Full record

SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2024

Success with incrementally faster times to endovascular therapy (SWIFT-EVT): A systematic review and meta-analysis.

Brittney Legere, Ahmed Mohamed, Salah Elsherif, Razan Saqqur, David Schoenfeld, Anna M Slebonick, Michael McCartin, James Price, Kori S Zachrison, Jonathan A Edlow and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brittney LegereDepartment of Applied Human Sciences, University of Guelph, Guelph, Ontario, Canada. Electronic address: blegere@alumni.uoguelph.ca.
Ahmed MohamedDepartment of Physiology, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada. Electronic address: aahmed.mohamed@mail.utoronto.ca.
Salah ElsherifDepartment of Health Sciences, Queens University, Kingston, Ontario, Canada. Electronic address: 19sae3@queensu.ca.
Razan SaqqurDepartment of Health, University of Waterloo, Waterloo, Ontario, Canada. Electronic address: rsaqqur@uwaterloo.ca.
David SchoenfeldDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA. Electronic address: dschoenf@bidmc.harvard.edu.
Anna M SlebonickDrexel University School of Medicine, Philadelphia, PA, USA. Electronic address: ams3283@drexel.edu.
Michael McCartinSection of Emergency Medicine, University of Chicago, Chicago, IL, USA. Electronic address: michael.mccartin@bsd.uchicago.edu.
James PriceDepartment of Emergency Medicine, Cambridge University NHS Trust, Cambridge, UK. Electronic address: james.price@eaaa.org.uk.
Kori S ZachrisonDepartment of Emergency Medicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA. Electronic address: kzachrison@mgb.org.
Jonathan A EdlowDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA. Electronic address: jedlow@bidmc.harvard.edu.
Maher SaqqurDepartment of Neurology, University of Toronto, Mississauga, ON, Canada. Electronic address: Maher.saqqur@thp.ca.
Ashfaq ShuaibDepartment of Neurology, University of Alberta, Edmonton, AB, Canada. Electronic address: Ashfaq.shuaib@ualberta.ca.
Stephen H ThomasDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA; Blizard Institute for Neuroscience, Surgery, & Trauma, Barts & The London School of Medicine, London, UK. Electronic address: shthoma1@bidmc.harvard.edu.

Funding

Addressing Racial/Ethnic Disparities in Stroke Care Access Using Hospital Transfer NetworksR01AG079887 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Korilyn Sauser Zachrison · 2023 to 2026
$2.9M
Chicago Stroke Trials ConsortiumU24NS107233 · NINDS · UNIVERSITY OF CHICAGO · PI Shyam Prabhakaran · 2018 to 2026
$2.8M
NIA NIH HHS R01 AG079887NINDS NIH HHS U24 NS107233
6 · The paper itself

Abstract

backgroundA major systematic review and meta-analysis assessing trial data through 2014 (the Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials, HERMES) demonstrated that particularly over the initial six hours of acute ischemic stroke (AIS), rapid performance of endovascular therapy (EVT) markedly improves outcomes. The current analysis, Success with Incrementally Faster Times to EVT (SWIFT-EVT), aimed to provide an updated metric summarizing latest estimates for modified Rankin Scale (mRS) improvements accrued by streamlining time to EVT.

methodsA systematic review and meta-analysis was conducted using electronic databases. Eligible studies reported a time-benefit slope with times from AIS onset (or time last known normal) to EVT commencement; the predictor was onset-to-groin (OTG) time. Primary and secondary outcomes were 90-day functional independence (mRS 0-2) and 90-day excellent function (mRS 0-1), respectively.

resultsFive studies were included. Results showed increased change of good outcome with each hour of pre-EVT time savings for mRS 0-2 for 0-270' (OR 1.25, 95 % CI 1.16-1.35, I

conclusionsEach hour saved from AIS onset to EVT start is associated with a 22-25 % increased odds of achieving functional independence, a useful metric to inform patient-specific and systems planning decisions.

Indexed as

Disability EvaluationEndovascular ProceduresFunctional StatusIschemic StrokeRecovery of FunctionTime-to-TreatmentAgedFemaleHumansMaleMiddle AgedRisk FactorsTime FactorsTreatment OutcomeEmergency medical servicesEndovascular therapyHelicopter transportStrokeTreatment time

Identifiers

PMID39182706
PMCPMC13032828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.