Evidence map›Paper›PMID 39182302›Full record

ArticleMedical image analysis2024

MA-SAM: Modality-agnostic SAM adaptation for 3D medical image segmentation.

Cheng Chen, Juzheng Miao, Dufan Wu, Aoxiao Zhong, Zhiling Yan, Sekeun Kim, Jiang Hu, Zhengliang Liu, Lichao Sun, Xiang Li and 3 more

Abstract read
In one paragraph

Article in Medical image analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  6. Article
  7. Review
  8. Unleashing Diffusion and State Space Models for Medical Image Segmentation.Journal of imaging informatics in medicine · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  18. Review
  19. TriSAM: Tri-Plane SAM for Zero-Shot Cortical Blood Vessel Segmentation in VEM Images.IEEE journal of biomedical and health informatics · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cheng ChenCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Juzheng MiaoDepartment of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Dufan WuCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Aoxiao ZhongCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Zhiling YanDepartment of Computer Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Sekeun KimCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jiang HuCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Zhengliang LiuCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; School of Computing, The University of Georgia, Athens, GA 30602, USA.
Lichao SunDepartment of Computer Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Xiang LiCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xli60@mgh.harvard.edu.
Tianming LiuSchool of Computing, The University of Georgia, Athens, GA 30602, USA.
Pheng-Ann HengDepartment of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Quanzheng LiCenter of Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Funding

FiberNET: Deep learning to evaluate brain tract integrity worldwide and in ADRF1AG057892 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2020 to 2023
$2.6M
Deep learning Based Phenotyping and Treatment Optimization for Heart Failure with Preserved Ejection FractionR01HL159183 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LI, QUANZHENG · 2022 to 2025
$2.3M
Identification of Multi-modal Imaging Biomarkers for Early Prediction of MCI-AD Conversion via Multigraph RepresentationR03AG078625 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LI, XIANG · 2022 to 2022
$329k
NHLBI NIH HHS R01 HL159183NIA NIH HHS R03 AG078625NIA NIH HHS RF1 AG057892
6 · The paper itself

Abstract

The Segment Anything Model (SAM), a foundation model for general image segmentation, has demonstrated impressive zero-shot performance across numerous natural image segmentation tasks. However, SAM's performance significantly declines when applied to medical images, primarily due to the substantial disparity between natural and medical image domains. To effectively adapt SAM to medical images, it is important to incorporate critical third-dimensional information, i.e., volumetric or temporal knowledge, during fine-tuning. Simultaneously, we aim to harness SAM's pre-trained weights within its original 2D backbone to the fullest extent. In this paper, we introduce a modality-agnostic SAM adaptation framework, named as MA-SAM, that is applicable to various volumetric and video medical data. Our method roots in the parameter-efficient fine-tuning strategy to update only a small portion of weight increments while preserving the majority of SAM's pre-trained weights. By injecting a series of 3D adapters into the transformer blocks of the image encoder, our method enables the pre-trained 2D backbone to extract third-dimensional information from input data. We comprehensively evaluate our method on five medical image segmentation tasks, by using 11 public datasets across CT, MRI, and surgical video data. Remarkably, without using any prompt, our method consistently outperforms various state-of-the-art 3D approaches, surpassing nnU-Net by 0.9%, 2.6%, and 9.9% in Dice for CT multi-organ segmentation, MRI prostate segmentation, and surgical scene segmentation respectively. Our model also demonstrates strong generalization, and excels in challenging tumor segmentation when prompts are used. Our code is available at: https://github.com/cchen-cc/MA-SAM.

Indexed as

AlgorithmsImaging, Three-DimensionalHumansMagnetic Resonance ImagingMaleTomography, X-Ray ComputedFoundation modelMedical image segmentationSegment anything

Identifiers

PMID39182302
PMCPMC11381141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.