Evidence map›Paper›PMID 39182136›Full record

ArticleVirology journal2024

STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.

Wenfeng He, Hongtao Chang, Chen Li, Chenlong Wang, Longxi Li, Guoqing Yang, Jing Chen, Huimin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenfeng He *College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Hongtao Chang *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
Chen Li *College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Chenlong WangCollege of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Longxi LiCollege of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Guoqing YangCollege of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Jing ChenCollege of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Huimin LiuCollege of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China. liuhuimin@henau.edu.cn.

Funding

National Natural Science Foundation of China 31902268Youth Backbone Teachers' Training Program of Colleges and Universities of Henan Province 2021GGJS034
6 · The paper itself

Abstract

Serine/threonine kinase receptor-associated protein (STRAP) serves as a scaffold protein and is engaged in a variety of cellular activities, although its importance in antiviral innate immunity is unknown. We discovered that STRAP works as an interferon (IFN)-inducible positive regulator, facilitating type I IFN signaling during pseudorabies virus infection. Mechanistically, STRAP interacts with TBK1 to activate type I IFN signaling. Both the CT and WD40 7 - 6 domains contribute to the function of STRAP. Furthermore, TBK1 competes with PRV-UL50 for binding to STRAP, and STRAP impedes the degradation of TBK1 mediated by PRV-UL50, thereby increasing the interaction between STRAP and TBK1. Overall, these findings reveal a previously unrecognized role for STRAP in innate antiviral immune responses during PRV infection. STRAP could be a potential therapeutic target for viral infectious diseases.

Indexed as

Herpesvirus 1, SuidImmunity, InnateInterferon Type IProtein Serine-Threonine KinasesAnimalsCell LineProtein BindingPseudorabiesRNA-Binding ProteinsSignal TransductionUp-RegulationInterferon Type IProtein Serine-Threonine KinasesRNA-Binding ProteinsTBK1 protein, humanAntiviral immunityPseudorabies virusSTRAPTBK1Type I interferon

Identifiers

PMID39182136
PMCPMC11344311

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.