Evidence map›Paper›PMID 39182082›Full record

ArticleClinical epigenetics2024

Biological aging mediates the association between periodontitis and cardiovascular disease: results from a national population study and Mendelian randomization analysis.

Zhaoqi Zhang, Xingru Zhao, Shang Gao, An Li, Ke Deng, Kai Yang, Wei Liu, Mi Du

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhaoqi ZhangThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xingru ZhaoThe First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
Shang GaoThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
An LiDepartment of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Ke DengDivision of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
Kai YangThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wei LiuThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China. weiliu800109@163.com.
Mi DuSchool and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. mi.du@sdu.edu.cn.

Funding

People's Government, Shandong Province, China N0.tsqn201909186
6 · The paper itself

Abstract

backgroundThe relationship between periodontitis and cardiovascular disease (CVD) has been extensively studied, but the role of biological aging in this relationship remains poorly understood. This study is dedicated to investigating the effect of periodontitis on the incidence of CVD and to elucidating the potential mediating role of biological aging. Furthermore, this study will seek to elucidate the causal association between periodontitis, CVD, and biological aging.

methodsWe included 3269 participants from the National Health and Nutrition Examination Survey (2009-2014) with diagnostic information on periodontitis and composite CVD events. Biological aging was evaluated by utilizing both the Klemera-Doubal method's calculated biological age (KDMAge) and phenotypic age (PhenoAge). Logistic regression, restricted cubic spline (RCS) analysis, and subgroup analysis were used for data analysis. Mediation analysis was employed to explore the mediating role of biological aging. Subsequently, Mendelian randomization (MR) analyses were performed using genome-wide association study databases to explore potential causal relationships between periodontitis, CVD, and biological aging.

resultsPeriodontitis was associated with a higher risk of CVD. Participants with periodontitis were found to have increased levels of biological aging, and elevated levels of biological aging were associated with increased CVD risk. Mediation analyses showed a partial mediating effect of biological aging (PhenoAge: 44.6%; KDMAge: 22.9%) between periodontitis and CVD risk. MR analysis showed that periodontitis played a causal role in increasing the risk of small vessel stroke, while myocardial infarction was found to increase the risk of periodontitis. In addition, reverse MR analysis showed that phenotypic aging can increase the risk of periodontitis, and there is a two-way causal relationship between CVD and biological aging.

conclusionsPeriodontitis is associated with an increased CVD risk, partially mediated by biological aging, with a complex causal interrelationship. Targeted interventions for periodontal health may slow the biological aging processes and reduce CVD risk.

Indexed as

AgingCardiovascular DiseasesGenome-Wide Association StudyMendelian Randomization AnalysisPeriodontitisAdultAgedFemaleHumansIncidenceMaleMiddle AgedNutrition SurveysRisk FactorsBiological agingCardiovascular diseaseCausal associationMediating effectPeriodontitis

Identifiers

PMID39182082
PMCPMC11344936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.