Evidence map›Paper›PMID 39181989›Full record

ReviewMolecular diagnosis & therapy2024

Is There a Role for FAPI PET in Urological Cancers?

Naima Ortolan, Luca Urso, Ilaria Zamberlan, Luca Filippi, Nicolò Maria Buffi, Corrado Cittanti, Licia Uccelli, Mirco Bartolomei, Laura Evangelista

Abstract readReview
In one paragraph

Review in Molecular diagnosis & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Head-to-head comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Review
  4. Diagnostic accuracy ofFrontiers in medicine · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naima OrtolanDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
Luca UrsoDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy. rsulcu@unife.it.ORCID 0000-0002-3007-3898
Ilaria ZamberlanDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
Luca FilippiNuclear Medicine Unit, Department of Oncohematology, Fondazione PTV Policlinico Tor Vergata University Hospital, Rome, Italy.
Nicolò Maria BuffiDepartment of Urology, IRCCS-Humanitas Research Hospital, Milan, Italy.
Corrado CittantiDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
Licia UccelliDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
Mirco BartolomeiNuclear Medicine Unit, Onco-Hematology Department, University Hospital of Ferrara, Ferarra, Italy.
Laura EvangelistaDepartment of Biomedical Science, Humanitas University, Pieve Emanuele, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work aims to investigate the utility of positron emission tomography/computed tomography (PET/CT) with fibroblast activation protein inhibitors (FAPI) in urological neoplasms, including prostate cancer, urothelial carcinoma, and renal cell carcinoma. Although the available data are very preliminary, FAPI PET showed potential for detecting primary prostate cancer with low prostate-specific membrane antigen expression, while prostate-specific membrane antigen PET/CT outperformed FAPI PET/CT in detecting biochemical recurrence. In urothelial carcinoma, FAPI PET/CT demonstrated increased detection rates compared with deoxy-2-[18F]fluoro-D-glucose PET/CT, in particular in small lymph node metastases, whose identification is still an unmet clinical need. Limited data are available for renal cell carcinoma. In conclusion, FAPI PET emerges as a promising imaging modality for urological neoplasms, in particular bladder cancer. Further research is warranted to establish its role in guiding therapeutic decisions and as a potential novel theranostic agent.

Indexed as

Positron Emission Tomography Computed TomographyUrologic NeoplasmsEndopeptidasesFibroblast Activation Protein AlphaFluorodeoxyglucose F18HumansMaleMembrane ProteinsPositron-Emission TomographyRadiopharmaceuticalsEndopeptidasesFibroblast Activation Protein AlphaFluorodeoxyglucose F18Membrane ProteinsRadiopharmaceuticals

Identifiers

PMID39181989
PMCPMC11512897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.