ArticleNature communications2024
An output-null signature of inertial load in motor cortex.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Locomotion engages context-dependent motor strategies for head stabilization in primates.Communications biology · 2026Article
- High performance sorting of motor unit action potentials with EMUsort.bioRxiv : the preprint server for biology · 2026Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- Spinal interneuron population dynamics underlying flexible pattern generation.Nature communications · 2025Article
- Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025Article
- Two premotor areas (6aα and 6aγ) involved in motor preparation and execution during visually guided locomotion in the cat.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cortical sculpting of a rhythmic motor program.bioRxiv : the preprint server for biology · 2025Article
- Gait speed-related changes in electrocortical activity in younger and older adults.Journal of neurophysiology · 2025Article
- MODELING TRAJECTORIES USING FUNCTIONAL LINEAR DIFFERENTIAL EQUATIONS.The annals of applied statistics · 2024Article
- Identifying Interpretable Latent Factors with Sparse Component Analysis.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
4 authors.
Funding
Abstract
Coordinated movement requires the nervous system to continuously compensate for changes in mechanical load across different conditions. For voluntary movements like reaching, the motor cortex is a critical hub that generates commands to move the limbs and counteract loads. How does cortex contribute to load compensation when rhythmic movements are sequenced by a spinal pattern generator? Here, we address this question by manipulating the mass of the forelimb in unrestrained mice during locomotion. While load produces changes in motor output that are robust to inactivation of motor cortex, it also induces a profound shift in cortical dynamics. This shift is minimally affected by cerebellar perturbation and significantly larger than the load response in the spinal motoneuron population. This latent representation may enable motor cortex to generate appropriate commands when a voluntary movement must be integrated with an ongoing, spinally-generated rhythm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.