Evidence map›Paper›PMID 39181693›Full record

Observational studyAJNR. American journal of neuroradiology2025

The Etiology of Intracranial Artery Stenosis in Autoimmune Rheumatic Diseases: An Observational High-Resolution MR Imaging Study.

Shun Li, Qiuyu Yu, Yangzhong Zhou, Manqiu Ding, Huanyu Zhou, Yiyang Liu, Yinxi Zou, Haoyao Guo, Yuelun Zhang, Mengtao Li and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shun LiFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0003-2699-2784
Qiuyu YuFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yangzhong ZhouDepartment of Rheumatology and Clinical Immunology (Y. Zhou., Mengtao Li), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Manqiu DingFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huanyu ZhouFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yiyang LiuFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yinxi ZouFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haoyao GuoFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yuelun ZhangCenter for Prevention and Early Intervention (Y. Zhang), National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Mengtao LiDepartment of Rheumatology and Clinical Immunology (Y. Zhou., Mengtao Li), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Mingli LiDepartment of Radiology (Mingli Li), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0001-8456-0686
Yan XuFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Weihai XuFrom the Department of Neurology (S.L., Q.Y., M.D., H.Z., Y.L., Y. Zou, H.G., Y.X., W.X.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China xuwh@pumch.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAutoimmune rheumatic diseases (AIRD) can cause intracranial artery stenosis (ICAS) and lead to stroke. This study aimed to characterize patients with ICAS associated with AIRD. MATERIALS AND

methodsUsing data from a high-resolution MR imaging database, we retrospectively reviewed patients with AIRD with ICAS. Stratification into vasculitis, atherosclerosis, and mixed atherovasculitis subtypes was based on imaging findings, followed by a comparative analysis of clinical characteristics and outcomes across these subgroups.

resultsAmong 139 patients (mean, 45.1 [SD, 17.3] years; 64.7% women), 56 (40.3%) were identified with vasculitis; 57 (41.0%), with atherosclerosis; and 26 (18.7%), with mixed atherovasculitis. The average interval from AIRD onset to high-resolution MRI was 5 years. Patients with vasculitis presented at a younger age of AIRD onset (mean, 34.5 [SD, 19.4] years), nearly 10 years earlier than other groups (

conclusionsIntracranial arteries are injured and lead to heterogeneous disease courses when exposed to AIRD and cardiovascular risk factors. While atherosclerosis acceleration is common, vasculitis may further contribute to the early development of occlusion and multiple artery involvement. Varied intracranial arteriopathies may result in different outcomes.

Indexed as

Autoimmune DiseasesMagnetic Resonance AngiographyMagnetic Resonance ImagingRheumatic DiseasesAdultAgedComorbidityConstriction, PathologicFemaleHumansMaleMiddle AgedRetrospective StudiesRisk Factors

Identifiers

PMID39181693
PMCPMC11878964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.