Evidence map›Paper›PMID 39181579›Full record

ReviewCurrent topics in membranes2024

Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis.

Sumit Bandyopadhyay, Daniel Adebayo, Eseiwi Obaseki, Hanaa Hariri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in membranes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026
    Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sumit BandyopadhyayDepartment of Biological Sciences, Wayne State University, Detroit, MI, United States.
Daniel AdebayoDepartment of Biological Sciences, Wayne State University, Detroit, MI, United States.
Eseiwi ObasekiDepartment of Biological Sciences, Wayne State University, Detroit, MI, United States.
Hanaa HaririDepartment of Biological Sciences, Wayne State University, Detroit, MI, United States. Electronic address: hanaa.hariri@wayne.edu.

Funding

Subcellular mechanisms coupling lipid synthesis and methionine metabolismR35GM150892 · NIGMS · WAYNE STATE UNIVERSITY · PI Hanaa Hariri · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150892
6 · The paper itself

Abstract

Lysosomes are more than just cellular recycling bins; they play a crucial role in regulating key cellular functions. Proper lysosomal function is essential for growth pathway regulation, cell proliferation, and metabolic homeostasis. Impaired lysosomal function is associated with lipid storage disorders and neurodegenerative diseases. Lysosomes form extensive and dynamic close contacts with the membranes of other organelles, including the endoplasmic reticulum, mitochondria, peroxisomes, and lipid droplets. These membrane contacts sites (MCSs) are vital for many lysosomal functions. In this chapter, we will explore lysosomal MCSs focusing on the machinery that mediates these contacts, how they are regulated, and their functional implications on physiology and pathology.

Indexed as

Cell CommunicationHomeostasisLysosomesAnimalsHumansIntracellular MembranesLipid homeostasisLysosomesMembrane contact sitesNutrient sensingOrganelles communication

Identifiers

PMID39181579
PMCPMC12570271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.