Evidence map›Paper›PMID 39181563›Full record

Observational studyBMJ open2024

Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA.

Sally M Vanegas, Silvia Curado, Akash Gujral, Gabriela Valverde, Susan Parraga, Jose O Aleman, Migdalia Reid, Brian Elbel, Ann Marie Schmidt, Sean P Heffron and 11 more

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sally M VanegasDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Silvia CuradoDepartment of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
Akash GujralDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Gabriela ValverdeDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Susan ParragaDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Jose O AlemanDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Migdalia ReidDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Brian ElbelDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Ann Marie SchmidtDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Sean P HeffronDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Eran SegalDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Huilin LiDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Courtney AbramsDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Mary A SevickDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Collin PoppDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Evelyn ArmijosDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Ericka N MerriwetherDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Valentina IvezajDepartment of Medicine, Yale University, New Haven, Connecticut, USA.
Christine Ren-FieldingDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Manish ParikhDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Melanie JayDepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USA melanie.jay@nyulangone.org.ORCID 0000-0001-7343-3120

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Training Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9M
Metabolic Flux Analysis of Obesity-Associated Inflammation in Weight LossK08DK117064 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ALEMAN, JOSE ORLANDO · 2019 to 2022
$823k
Effects of Bariatric Surgery on HDL and Platelet FunctionK23HL135398 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HEFFRON, SEAN PATRICK · 2017 to 2021
$764k
Mentoring the next generation of trainees in patient-oriented, community engaged research in obesity and health equityK24HL165161 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Melanie Jay · 2023 to 2026
$507k
NCATS NIH HHS UL1 TR001445NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016087NHLBI NIH HHS K23 HL135398NHLBI NIH HHS K24 HL165161NHLBI NIH HHS T32 HL098129NIDDK NIH HHS K08 DK117064NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

purposeWe developed a comprehensive sleeve gastrectomy (SG) weight loss study cohort and biorepository to uncover mechanisms, biomarkers and predictive factors of weight loss, weight maintenance and amelioration of obesity-related comorbidities. For this purpose, we collected psychosocial, anthropometric, clinical data and a variety of samples pre-surgery, intraoperatively and 1.5, 3, 12 and 24 months post-surgery. For longer-term assessment, the collection of psychosocial and anthropometric data was extended to 10 years. Here, we present in-depth characterisation of the cohort and detailed overview of study procedures as a foundation for future analyses.

participantsWe consented 647 participants between June 2017 and March 2020 from two bariatric surgery clinics in New York City-one major urban hospital and one private hospital. Of 355 participants who provided baseline data, 300 underwent SG. Of these, 79% are females with an average age of 38 years, 68% are Hispanic, 20% are non-Hispanic Black and 11% are non-Hispanic White. FINDINGS TO DATE: We collected intraoperative adipose and stomach tissues from 282 patients and biosamples (blood, urine, saliva, stool) from 245 patients at 1.5 months, 238 at 3 month, 218 at 12 months and 180 at 24 months post-surgery. We are currently collecting anthropometric and psychosocial data annually until 10 years post-surgery. Data analysis is currently underway. FUTURE PLANS: Our future research will explore the variability in weight loss outcomes observed in our cohort, particularly among Black and Hispanic patients in comparison to their White counterparts. We will identify social determinants of health, metabolic factors and other variables that may predict weight loss success, weight maintenance and remission of obesity-related comorbidities. Additionally, we plan to leverage our biorepository for collaborative research studies. We will complete long-term follow-up data by December 2031. We plan to apply for funding to expand biosample collection through year 10 to provide insights into the mechanisms of long-term weight maintenance.

Indexed as

GastrectomyObesity, MorbidWeight LossAdultBariatric SurgeryCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedResearch DesignUnited StatesAdult surgeryBariatric SurgeryObesityObservational Study

Identifiers

PMID39181563
PMCPMC11344502

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.