Evidence map›Paper›PMID 39181129›Full record

ArticleCell stem cell2024

Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.

Le Xu, Chunting Tan, Justinn Barr, Nicole Talaba, Jamie Verheyden, Ji Sun Chin, Samvel Gaboyan, Nikita Kasaraneni, Ruth M Elgamal, Kyle J Gaulton and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Le XuDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Chunting TanDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Justinn BarrDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Nicole TalabaDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Jamie VerheydenDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Ji Sun ChinDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Samvel GaboyanPulmonary and Critical Care Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Nikita KasaraneniPulmonary and Critical Care Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ruth M ElgamalDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Kyle J GaultonDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Grace LinDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Kamyar AfsharDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Eugene GoltsDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, University of California, San Diego, La Jolla, CA, USA.
Angela MeierDepartment of Anesthesiology, Division of Critical Care, University of California, San Diego, La Jolla, CA, USA.
Laura E Crotty AlexanderPulmonary and Critical Care Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Zea BorokDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yufeng ShenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA; JP Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
David J McCulleyDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Xin SunDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: xinsun@health.ucsd.edu.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Beyond the Barrier: Alveolar Epithelial Cell Biology in Health and DiseaseR35HL135747 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BOROK, ZEA · 2017 to 2023
$6.8M
Balancing Airway Progenitor versus Progeny: a Pathway from MitochondriaR01HL160019 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2024
$2.1M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Frontiers at the edge: Subpleural fibroblasts orchestrate pulmonary fibrosis progressionK99HL171830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI XU, LE · 2024 to 2025
$306k
NHLBI NIH HHS K99 HL171830NHLBI NIH HHS R01 HL160019NHLBI NIH HHS R35 HL135747NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

While all eukaryotic cells are dependent on mitochondria for function, in a complex tissue, which cell type and which cell behavior are more sensitive to mitochondrial deficiency remain unpredictable. Here, we show that in the mouse airway, compromising mitochondrial function by inactivating mitochondrial protease gene Lonp1 led to reduced progenitor proliferation and differentiation during development, apoptosis of terminally differentiated ciliated cells and their replacement by basal progenitors and goblet cells during homeostasis, and failed airway progenitor migration into damaged alveoli following influenza infection. ATF4 and the integrated stress response (ISR) pathway are elevated and responsible for the airway phenotypes. Such context-dependent sensitivities are predicted by the selective expression of Bok, which is required for ISR activation. Reduced LONP1 expression is found in chronic obstructive pulmonary disease (COPD) airways with squamous metaplasia. These findings illustrate a cellular energy landscape whereby compromised mitochondrial function could favor the emergence of pathological cell types.

Indexed as

Cell DifferentiationMitochondriaMitochondrial ProteinsStem CellsAnimalsApoptosisATP-Dependent ProteasesCell ProliferationHumansMiceMice, Inbred C57BLPulmonary Disease, Chronic ObstructiveATP-Dependent ProteasesLONP1 protein, mouseMitochondrial Proteinsairway homeostasisATF4BOKCOPDdifferentiated progeny cellsinfluenza infectionintegrated stress responselung epithelial cellsmitochondriaprogenitor basal cells

Identifiers

PMID39181129
PMCPMC12398276

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.