ArticleNeuropeptides2024
Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance.
Article in Neuropeptides, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Article
- The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation.Translational psychiatry · 2026Article
- Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Review
- A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia.Molecular metabolism · 2025Article
- Investigation of serum agouti-related peptide levels in women with polycystic ovary syndrome.Revista da Associacao Medica Brasileira (1992) · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes are not fully understood. In this study, we show that induction of the unfolded protein response transcription factor, spliced X-box binding protein 1 (Xbp1s), in Agouti-Related Peptide (AgRP) neurons alone, is sufficient to not only protect against but also significantly reverse diet-induced obesity (DIO) as well as improve leptin and insulin sensitivity, despite activation of endoplasmic reticulum stress. We also demonstrate that constitutive expression of Xbp1s in AgRP neurons contributes to improved insulin sensitivity and glucose tolerance. Together, our results identify critical molecular mechanisms linking ER stress in arcuate AgRP neurons to acute leptin and insulin resistance as well as liver glucose metabolism in DIO and diabetes.
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