Evidence map›Paper›PMID 39180827›Full record

ReviewCurrent opinion in microbiology2024

Fungal effectors: past, present, and future.

Gengtan Li, Madison Newman, Houlin Yu, Maryam Rashidzade, Domingo Martínez-Soto, Ana Caicedo, Kelly S Allen, Li-Jun Ma

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Studying Cell Wall-Associated Effectors in U. maydis.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Evidence thatbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gengtan LiDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Madison NewmanDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Organismal and Evolutionary Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Houlin YuDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Plant Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Maryam RashidzadeDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Plant Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Department of Biology, Centro de Investigación Científica y de Educación Superior de Ensenada, BC, Mexico.
Domingo Martínez-SotoDepartment of Microbiology, Centro de Investigación Científica y de Educación Superior de Ensenada, BC, Mexico.
Ana CaicedoOrganismal and Evolutionary Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Plant Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Department of Biology, Centro de Investigación Científica y de Educación Superior de Ensenada, BC, Mexico.
Kelly S AllenDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Plant Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Li-Jun MaDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Organismal and Evolutionary Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA; Plant Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA. Electronic address: lijun@biochem.umass.edu.

Funding

Identify virulence factors that facilitate Fusarium keratitisR01EY030150 · NEI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MA, LI-JUN · 2019 to 2023
$1.9M
NEI NIH HHS R01 EY030150
6 · The paper itself

Abstract

Fungal effector proteins function at the interfaces of diverse interactions between fungi and their plant and animal hosts, facilitating interactions that are pathogenic or mutualistic. Recent advancements in protein structure prediction have significantly accelerated the identification and functional predictions of these rapidly evolving effector proteins. This development enables scientists to generate testable hypotheses for functional validation using experimental approaches. Research frontiers in effector biology include understanding pathways through which effector proteins are secreted or translocated into host cells, their roles in manipulating host microbiomes, and their contribution to interacting with host immunity. Comparative effector repertoires among different fungal-host interactions can highlight unique adaptations, providing insights for the development of novel antifungal therapies and biocontrol strategies.

Indexed as

Fungal ProteinsFungiHost-Pathogen InteractionsAnimalsPlant DiseasesPlantsFungal Proteins

Identifiers

PMID39180827
PMCPMC11442010

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.