Evidence map›Paper›PMID 39180612›Full record

ArticleBulletin of mathematical biology2024

Onset of Spontaneous Filling and Voiding Cycles in the Lower Urinary Tract: A Modeling Study.

Roberto Nunez, Elie Alhajjar, Daniel Jaskowak, Zachary C Danziger, Giovanna Guidoboni

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In one paragraph

Article in Bulletin of mathematical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Roberto NunezDepartment Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO, USA.
Elie AlhajjarDivision of Engineering and Applied Sciences, RAND, Arlington, VA, USA.
Daniel JaskowakDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.
Zachary C DanzigerDepartment of Rehabilitation Medicine, Division of Physical Therapy, Emory University, Atlanta, GA, USA.
Giovanna GuidoboniMaine College of Engineering and Computing, University of Maine, Orono, ME, USA. giovanna.guidoboni@maine.edu.ORCID 0000-0001-7470-0171

Funding

A new hybrid modeling framework combining biophysics and deep learning to predict and optimize peripheral neuromodulation outcomes in lower urinary tract diseaseR01DK133605 · NIDDK · FLORIDA INTERNATIONAL UNIVERSITY · PI Zachary C Danziger · 2022 to 2026
$3.1M
A New Paradigm for Systems Physiology Modeling: Biomechanistic Learning Augmentation with Deep Differential Equation Representations (BLADDER)OT2OD030524 · OD · FLORIDA INTERNATIONAL UNIVERSITY · PI DANZIGER, ZACHARY C · 2020 to 2021
$1.9M
NIDDK NIH HHS R01 DK133605NIH HHS NIH OT2OD030524NIH HHS NIH R01DK133605NIH HHS OT2 OD030524
6 · The paper itself

Abstract

Spontaneous filling and voiding cycles represent a key dynamical feature of the healthy lower urinary tract. Some urinary tract dysfunctions, such as over-flow incontinence, may alter the natural occurrence of these cycles. As the function of the lower urinary tract arises from the interplay of a multitude of factors, it is difficult to determine which of them can be modulated to regain spontaneous cycles. In this study, we develop a mathematical model of the lower urinary tract that can capture filling and voiding cycles in the form of periodic solutions of a system of ordinary differential equations. After experimental validation, we utilize this model to study the effect that several physiological quantities have on the onset of cycles. We find that some parameters have an associated numerical threshold that determines whether the system exhibits healthy cycles or settles in a state of constant overflow.

Indexed as

Mathematical ConceptsModels, BiologicalUrinationUrodynamicsComputer SimulationFemaleHumansUrinary BladderFilling voiding cyclesLower urinary tractMathematical modelingMathematical modeling of organ function

Identifiers

PMID39180612
PMCPMC12023232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.