Evidence map›Paper›PMID 39180607›Full record

ReviewImmunologic research2024

Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature.

Yucai Ye, Juan Wang, Bahu Bao, Guorong Chen, Aoyan Hu, Jingzi Sun, Weiying Liu

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yucai YeDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Juan WangDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Bahu BaoDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Guorong ChenDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Aoyan HuDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Jingzi SunDepartment of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Weiying LiuDepartment of Respiratory and Critical Care Medicine, the First Hospital of Lanzhou University, No.1 Donggang West Road, Chengguan District, Lanzhou City, 730000, Gansu Province, China. Lwy70828@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Good syndrome (GS), a rare acquired immunodeficiency disorder characterized by thymoma and hypogammaglobulinemia, predisposes individuals to recurrent infections. This study reports a case of a 37-year-old male GS with multiple pulmonary infections and reviews relevant literature. The patient, with a history of thymoma resection, experienced multiple hospitalizations due to lung infections and neutropenia. The alveolar lavage fluid was detected by macro-genomic sequencing (NGS) to detect multiple pathogens, and targeted anti-infective and immunity-enhancing treatments led to improved symptoms and normal neutrophil counts. A literature review of 98 case reports from 2000 to 2023 was conducted, summarizing the associated diseases and pathogens in GS patients. Regular immunoglobulin monitoring in thymoma patients is essential for early GS diagnosis. When empirical antimicrobial therapy fails, mNGS for pathogen detection and targeted therapy are crucial, and regular IVIG injections can reduce infection rates in GS patients.

Indexed as

AgammaglobulinemiaAdultHumansImmunoglobulins, IntravenousMaleNeutropeniaRespiratory Tract InfectionsThymomaThymus NeoplasmsImmunoglobulins, IntravenousGood syndromeHypogammaglobulinemiaMultiple microbial pulmonary infectionsNeutropeniaThymoma

Identifiers

PMID39180607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.