ArticleJournal of cancer research and clinical oncology2024
Association between four insulin resistance surrogates and the risk of esophageal cancer: a prospective cohort study using the UK Biobank.
Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Associations of metabolic score for insulin resistance with type 2 diabetes, cancer, and all-cause mortality: a meta-analysis of cohort studies.Frontiers in endocrinology · 2026Pooled it
- The Associations Between the TyG Index and the Risk of Cancer-A Systematic Review and Meta-Analysis.Cancer medicine · 2025Pooled it
- Relationships of triglyceride-glucose-related indices with colorectal cancer incidence and mortality in an American population: a dose-response meta-analysis and cohort study.Lipids in health and disease · 2025Pooled it
- The association of triglyceride-glucose index with cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study.BMC cancer · 2026Article
- Association Between Triglyceride-Glucose Index and Risk of Cancer: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2026Review
- Post-treatment triglyceride-glucose index as survival protective factors in patients with esophageal squamous cell carcinoma.World journal of clinical oncology · 2026Article
- Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank.Frontiers in endocrinology · 2026Article
- Association of TyG-BMI and malnutrition with reduced survival outcomes in patients with cancer: a prospective study.Frontiers in nutrition · 2026Article
- Pretreatment TyG-BMI predicts CD19 CAR-T persistence and prognosis in diffuse large B-cell lymphoma.Frontiers in oncology · 2026Article
- Comprehensive evaluation of the prevalent insulin resistance indices for pan-cancer incidence and mortality prediction.Tropical medicine and health · 2025Article
- Anti-diabetic medications and cancer: links beyond glycemic and body weight control.Precision clinical medicine · 2025Review
- Associations between four insulin resistance (IR) surrogates and the risk of small cell lung cancer (SCLC).Scientific reports · 2025Article
- Which Surrogate Marker of Insulin Resistance Among Those Proposed in the Literature Better Predicts the Presence of Non-Metastatic Bladder Cancer?Journal of clinical medicine · 2025Article
- Insulin Resistance and Cancer.Journal of diabetes · 2025Article
- Research status of triglyceride glucose-body mass index (TyG-BMI index).Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study explored the association between triglyceride-glucose (TyG), TyG index with body mass index (TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), metabolic score for insulin resistance (IR) (METS-IR) and the risk of esophageal cancer.
methodsA total of 388,900 participants from the United Kingdom Biobank from 2006 to 2010 were included. Fine-Gray models, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curves were used to assess the association between the four IR surrogates and the risk of esophageal cancer, specifically, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC).
resultsTen years after recruitment, 0.16% (95%CI 0.11-0.26%) had esophageal cancer and 4.17% (95%CI 3.86-4.46%) are deceased. For each standard deviation increase in the TyG index, TyG-BMI, TG/HDL-C, and METS-IR, the risk of EAC increased by Hazard ratios (HR)1.16, 1.37, 1.08, and 1.36, respectively (all P < 0.05), while the risk of ESCC decreased by HRs 0.80, 0.67, 0.77, and 0.65, respectively. RCS analysis indicated that most relationships were nonlinear (P < 0.05). ROC curves showed that METS-IR had a more robust diagnostic efficacy than TyG, TyG-BMI, and TG/HDL-C.
conclusionTyG index, TyG-BMI, TG/HDL-C, and METS-IR were closely associated with the risk of EAC and ESCC. Additionally, METS-IR surpassed the other three IR indices in predicting and diagnosing the risks of EAC and ESCC. The METS-IR is expected to become a more effective metric for identifying populations at early risk of esophageal cancer and for improving risk stratification.
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