Evidence map›Paper›PMID 39180537›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Asthma as a risk factor and allergic rhinitis as a protective factor for COVID-19 severity: a case-control study.

Martha Débora Lira Tenório, Gabriel Valentim Dos Santos Menezes Siqueira, Gustavo Costa Caldas, Roque Pacheco de Almeida, Amélia Ribeiro de Jesus, Paulo Ricardo Martins-Filho

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martha Débora Lira TenórioGraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, SE, Brazil.
Gabriel Valentim Dos Santos Menezes SiqueiraDepartment of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil.
Gustavo Costa CaldasDepartment of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil.
Roque Pacheco de AlmeidaGraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, SE, Brazil.
Amélia Ribeiro de JesusGraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, SE, Brazil.
Paulo Ricardo Martins-FilhoGraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, SE, Brazil. prmartinsfh@gmail.com.ORCID http://orcid.org/0000-0001-8779-0727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe COVID-19 pandemic has resulted in significant global morbidity and mortality. The disease presents a broad clinical spectrum, significantly influenced by underlying comorbidities. While certain conditions are known to exacerbate COVID-19 outcomes, the role of chronic inflammatory airway diseases such as asthma and rhinitis in influencing disease severity remains controversial. This study investigates the association between asthma and allergic rhinitis and the severity of COVID-19 outcomes in a specific geographical region prior to widespread vaccine deployment.

methodsWe conducted a case-control study with unvaccinated adult patients who had laboratory-confirmed COVID-19 by polymerase chain reaction (PCR). Cases were defined as severe or critical COVID-19 patients requiring intensive care unit (ICU) admission, and controls were non-severe patients without signs of viral pneumonia or hypoxia. We utilized the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to assess the presence of asthma and allergic rhinitis. The association between these chronic inflammatory airway diseases and the severity of COVID-19 was evaluated using multivariate logistic regression analysis.

resultsA total of 122 patients were analyzed, with 61 in each group. The presence of asthma (9 patients) was associated with an increased likelihood of severe COVID-19 (OR = 13.0; 95% CI 1.27-133.74), while rhinitis (39 patients) was associated with a protective effect against severe outcomes (OR = 0.36; 95% CI 0.13-0.99). No significant association was found between the frequency of asthmatic episodes or the severity of rhinitis and the severity of COVID-19 outcomes.

conclusionThis study underscores the divergent effects of chronic inflammatory airway diseases on COVID-19 severity, with asthma associated with a higher likelihood of severe outcomes and rhinitis potentially offering protective effects. These findings enhance our understanding of the complex interactions between respiratory allergies and COVID-19, emphasizing the importance of targeted clinical management and public health strategies.

Indexed as

AsthmaCOVID-19Rhinitis, AllergicSeverity of Illness IndexAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProtective FactorsRisk FactorsSARS-CoV-2AsthmaCOVID-19RhinitisSARS-CoV-2

Identifiers

PMID39180537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.