Evidence map›Paper›PMID 39180341›Full record

ReviewCutaneous and ocular toxicology2025

Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides.

Hans A Raabe, Gertrude-Emilia Costin, David G Allen, Anna Lowit, Marco Corvaro, Lindsay O'Dell, Julie Breeden-Alemi, Kathryn Page, Monique Perron, Tara Flint Silva and 3 more

Abstract readReview
In one paragraph

Review in Cutaneous and ocular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Incorporating a dermal absorption route into high throughput toxicokinetic modeling.Journal of exposure science & environmental epidemiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hans A RaabeInstitute for In Vitro Sciences, Gaithersburg, MD, USA.
Gertrude-Emilia CostinInstitute for In Vitro Sciences, Gaithersburg, MD, USA.
David G AllenInotiv, Durham, NC, USA.
Anna LowitUS Environmental Protection Agency, Washington, DC, USA.
Marco CorvaroCorteva Agriscience, Rome, Italy.
Lindsay O'DellUS Environmental Protection Agency, Washington, DC, USA.
Julie Breeden-AlemiUS Environmental Protection Agency, Washington, DC, USA.
Kathryn PageThe Clorox Company, San Francisco, CA, USA.
Monique PerronUS Environmental Protection Agency, Washington, DC, USA.
Tara Flint SilvaUS Environmental Protection Agency, Washington, DC, USA.
Walter WesterinkCharles River Laboratories, Den Bosch, The Netherlands.
Elizabeth BakerPhysicians Committee for Responsible Medicine, Washington, DC, USA.
Kristie SullivanInstitute for In Vitro Sciences, Gaithersburg, MD, USA.

Funding

NIEHS NIH HHS HHSN273201400003CNIEHS NIH HHS HHSN273201500010C
6 · The paper itself

Abstract

Indexed as

IrritantsPesticidesSkinSkin Irritancy TestsAnimalsAnimal Testing AlternativesHumansRabbitsIrritantsPesticidescytokine releaseformulationnew approach methodologiesnon-animalpesticidereconstructed human epidermisskin corrosionskin irritation

Identifiers

PMID39180341
PMCPMC11847949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.