Evidence map›Paper›PMID 39180291›Full record

Observational studyJournal of the American Geriatrics Society2024

Clinical performance of existing diagnostic criteria for pneumonia in older emergency patients: A prospective cohort study.

Katherine M Hunold, Lorraine C Mion, Tanya R Gure, Andrew L Schwaderer, Matthew Exline, Courtney Hebert, Brent C Lampert, Lauren T Southerland, Julie A Stephens, Edward W Boyer and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katherine M HunoldDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-8938-0596
Lorraine C MionCollege of Nursing, The Ohio State University, Columbus, Ohio, USA.
Tanya R GureDivision of General Internal Medicine & Geriatrics, The Ohio State University, Columbus, Ohio, USA.
Andrew L SchwadererSection of Pediatric Nephrology, Indiana University, Indianapolis, Indiana, USA.
Matthew ExlineDepartment of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Courtney HebertDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Brent C LampertDivision of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.
Lauren T SoutherlandDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-3561-8332
Julie A StephensCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Edward W BoyerDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Michael HillDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Ching-Min B ChuDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Carson ReiderDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Jeffrey M CaterinoDepartment of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.

Funding

Urine antimicrobial proteins in older adults: aging, infection, & innate immunityR01AG050801 · NIA · OHIO STATE UNIVERSITY · PI CATERINO, JEFFREY M · 2016 to 2020
$2.8M
Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse ResearchK24DA037109 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOYER, EDWARD W · 2014 to 2025
$1.9M
Establishing and Implementing Pneumonia Diagnosis in ED Older Adults: A Mixed Methods ApproachK76AG074941 · NIA · OHIO STATE UNIVERSITY · PI Katherine Hunold Buck · 2022 to 2026
$1.2M
Improving Diagnostic Accuracy for Older Emergency Department Patients with Suspected Pneumonia: The Role of Diagnostic Criteria and Novel Antimicrobial PeptidesR03AG064379 · NIA · OHIO STATE UNIVERSITY · PI BUCK, KATHERINE HUNOLD · 2019 to 2020
$234k
NIA NIH HHS K76 AG074941NIA NIH HHS R01 AG050801NIA NIH HHS R01AG050801NIA NIH HHS R03 AG064379NIA NIH HHS R03AG064379NIDA NIH HHS K24 DA037109
6 · The paper itself

Abstract

backgroundPneumonia accounts for over half a million older adult emergency department (ED) visits annually, but ED pneumonia diagnosis is inaccurate. Geriatric-specific pneumonia diagnostic criteria exist for other settings; no prospective data exist to determine if application in the older adult ED population is feasible. The objective was to prospectively evaluate the utility of four current diagnostic criteria (Loeb; Modified McGeer; Infectious Disease Society of America/American Thoracic Society; American College of Emergency Physicians) in older adult ED patients.

methodsThis was a prospective, observational cohort study of older adult ED patients ≥65 years of age in two U.S. EDs with suspected pneumonia defined as having chest radiography ordered and treating physician suspicion. The standard we used for defining the presence, absence, or inability to determine a diagnosis of pneumonia diagnosis was expert physician chart adjudication. We report the summary statistics for demographic characteristics and symptoms/exam findings and sensitivity, specificity, and likelihood ratios with 95% confidence intervals of the existing diagnostic criteria. Pre-specified cutoff values of a positive LR >10 and a negative LR <0.3 were considered clinically significant.

resultsOf 135 patients enrolled, 27 had pneumonia by adjudicator review. Typical patient-reported pneumonia symptoms, such as fever (18.5%) and new/worse cough (51.9%), were not consistently present in pneumonia. The IDSA/ATS and ACEP criteria had positive LR >10 and negative LR <0.3; however, all confidence intervals included pre-specified cutoffs.

conclusionsOlder adults presented to the ED with low frequency of typical pneumonia symptoms. Although existing diagnostic definitions had promising test characteristics, they may not perform well enough for clinical application without refinement.

Indexed as

Emergency Service, HospitalPneumoniaAgedAged, 80 and overFemaleHumansMaleProspective StudiesSensitivity and SpecificityUnited Statesdiagnosticsemergency medicinepneumonia

Identifiers

PMID39180291
PMCPMC11572722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.