Evidence map›Paper›PMID 39180043›Full record

ArticleBMC health services research2024

Medication reviews by emergency department pharmacists in patients hospitalised for an adverse drug event: a cost study.

Rehana N Rahman, Suzanne Polinder, Bojan Nikolik, Amber E Hoek, Marjo J A Janssen, Stephanie C E Schuit, Patricia M L A van den Bemt, Fatma Karapinar-Çarkit

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In one paragraph

Article in BMC health services research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rehana N RahmanDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands. r.n.rahman@umcg.nl.
Suzanne PolinderDepartment of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Bojan NikolikDepartment of Clinical Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.
Amber E HoekDepartment of Emergency Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Marjo J A JanssenDepartment of Clinical Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.
Stephanie C E SchuitBoard of Directors, University Medical Center Groningen, Groningen, The Netherlands.
Patricia M L A van den BemtDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands.
Fatma Karapinar-ÇarkitDepartment of Clinical Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo perform a cost study of pharmacist-led medication reviews in patients with an acute hospitalization for adverse drug events.

methodEmergency department pharmacists performed medication reviews in patients hospitalized after visiting the emergency department for an adverse drug event (ADE). Control patients were hospitalized after an emergency department visit not related to an ADE and received usual care. The costs of the intervention were labour costs of the junior emergency department pharmacist and the cost savings consisted of costs of medication that was stopped or reduced during six months after the intervention. Sensitivity analyses were performed to evaluate different scenarios.

resultsIn the intervention group (n = 104) 113 medication changes led to stopping or reducing medication, accounting for averted costs of €22,850. In the control group (n = 112) 39 medication changes led to stopping or reducing medication, accounting for averted costs of €299. The mean labour costs of the intervention were €138 per patient, resulting in saved costs of €61 per patient per six months. Sensitivity analyses showed that if the intervention would be performed by a senior clinical pharmacist, there are no cost savings (€-21), if parts of the intervention would be executed by pharmacy technicians (e.g. administrative tasks), cost savings would be augmented to €87, if outliers in costs associated with medication reduction would be excluded, there are no cost savings (€-35) and if the costs of reduced medication were extrapolated to one year, cost savings would be €260.

conclusionIn this study, medication reviews by junior emergency department pharmacists in patients hospitalized after an emergency department visit for an ADE lead to a cost reduction over a six month period.

trial registrationThe main study is registered on the ISRCTN registry with trial ID ISRCTN12506329 on 06-03-2022.

Indexed as

Drug-Related Side Effects and Adverse ReactionsEmergency Service, HospitalHospitalizationPharmacistsPharmacy Service, HospitalAdultAgedFemaleHumansMaleMiddle AgedCosts and cost analysisDrug-related side effects and adverse reactionsDrug utilization reviewHealth care costsHospital emergency serviceMedical overuse

Identifiers

PMID39180043
PMCPMC11344293

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.