Evidence map›Paper›PMID 39179979›Full record

ArticleBMC gastroenterology2024

RARB associated with MSI, affects progression and prognosis of gastric cancer.

Xufan Cai, Wenfa Lin, Fang Wu, Guangyuan Song, Zhenyuan Qian, Yu Wang

Abstract read
In one paragraph

Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xufan Cai *Graduate School, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.
Wenfa Lin *Graduate School, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.
Fang WuGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, The Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
Guangyuan SongGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery, Zhejiang Provincial People's Hospital, The Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
Zhenyuan QianGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, The Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. 13858595659@163.com.
Yu WangCenter for Rehabilitation Medicine, Department of Anesthesiology, Zhejiang Provincial People's Hospital, The Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. wlwy4405@163.com.

Funding

Zhejiang Chinese Medicine University Postgraduate Scientific Research Fund Project No.Y202248712
6 · The paper itself

Abstract

Microsatellite instability (MSI) has been widely acknowledged as an important factor regulating tumor intrinsic biological behavior and affecting the survival of gastric cancer patients. Here, we firstly identified the RARB as a gene associated with MSI gastric cancer. RARB was downregulated in human gastric cancer tissues compared to paired paracancerous tissues, Knockdown of RARB accelerated the proliferation, invasion and migration of cancer cells in vitro. Mechanismly, RARB knockdown promoted epithelial-mesenchymal transition (EMT) process of gastric cancer. However, RARB

Indexed as

Cell ProliferationDisease ProgressionEpithelial-Mesenchymal TransitionMicrosatellite InstabilityReceptors, Retinoic AcidStomach NeoplasmsCell Line, TumorCell MovementDown-RegulationFemaleGene Knockdown TechniquesHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisReceptors, Retinoic Acidretinoic acid receptor betaGastric cancerMSIRARBTumor immune microenvironment

Identifiers

PMID39179979
PMCPMC11342619

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.