Evidence map›Paper›PMID 39179976›Full record

ArticleBMC nephrology2024

Peritoneal and renal DKK3 clearance in peritoneal dialysis.

Hagen Ehleiter, Julia Miranda, Dominik Boes, Uta Scheidt, Sibylle von Vietinghoff, Sebastian Schwab

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Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hagen Ehleiter *Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.
Julia Miranda *Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.
Dominik BoesKuratorium for Dialysis, KfH Renal Center, Bonn, Germany.
Uta ScheidtNephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.
Sibylle von Vietinghoff *Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.
Sebastian Schwab *Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany. Sebastian.Schwab@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis.

methodsDKK3 was assessed in serum, urine and dialysate in a prevalent adult peritoneal dialysis cohort and its concentration analyzed in relation to creatinine and clinical characteristics.

resultsHighest DKK3 concentrations were found in serum, followed by urine. Dialysate concentrations were significantly lower. Dialysate DKK3 correlated with both other compartments. Serum, dialysate and urine values were stable during three months of follow-up. Continuous ambulatory dialysis (CAPD) but not cycler-assisted peritoneal dialysis (CCPD) volume-dependently increased peritoneal DKK3 in relation to creatinine. RAAS blockade significantly decreased urinary, but not serum or peritoneal DKK3.

conclusionOur data provide a detailed characterization of DKK3 in peritoneal dialysis. They support the notion that the RAAS system is essential for renal DKK3 handling.

Indexed as

Adaptor Proteins, Signal TransducingPeritoneal DialysisAdultAgedBiomarkersChemokinesCreatinineDialysis SolutionsFemaleHumansIntercellular Signaling Peptides and ProteinsKidneyKidney Failure, ChronicMaleMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryAdaptor Proteins, Signal TransducingBiomarkersChemokinesCreatinineDialysis SolutionsDKK3 protein, humanIntercellular Signaling Peptides and ProteinsDKK3Peritoneal dialysisRAAS blockade

Identifiers

PMID39179976
PMCPMC11342714

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