ArticleBMC geriatrics2024
Risk of falls or fall-related injuries associated with potentially inappropriate medication use among older adults with dementia.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Champion-Led Deprescribing for Persons with Dementia in Primary Care: A Qualitative Study in Accountable Care Organizations.Journal of general internal medicine · 2026Trial
- Standardizing care for agitation in Alzheimer's disease, results from a randomized controlled trial of an integrated care pathway versus usual care - the StaN trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Dementia and the Impact of Acetylcholinesterase Inhibitors on Falls, Fractures and Mortality in a Geriatric Cohort: A 4-Year Follow-Up Study.Journal of clinical medicine · 2026Article
- Hospital Fall Prevention Practices and Implementation Strategies: A Multisite Observational Study.Journal of patient safety · 2026Article
- Potentially inappropriate medications related to two-year progression of mild cognitive impairment and dementia.European journal of clinical pharmacology · 2026Article
- Article
- Prevalence and association of fall-risk-increasing drugs (FRIDs) with fall-related head and non-head injuries in older adults: a retrospective database study.Scientific reports · 2025Observational
- Household Wealth and Potentially Inappropriate Medications in Persons With Dementia: Role of Comorbidities and Caregivers.Journal of the American Geriatrics Society · 2025Article
- Observational
- Trajectories of potentially inappropriate medication use among older adults in Saudi Arabia.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPotentially inappropriate medications (PIMs) are prevalent in older adults with dementia and subsequent falls or fall-related injuries. The present study determined the risk of falls or fall-related injuries associated with PIM use in older adults with dementia.
methodsThe National Health Insurance Service-Elderly Cohort Database 2.0 (NHIS-ECDB 2.0) was used for this self-controlled case series (SCCS) study. This study included 1430 participants who went through exposure and non-exposure periods of PIM application among patients with dementia and experienced outcome events of falls or fall-related injuries between January 2016 and December 2019. The incidence of falls or fall-related injuries during the exposure and post-exposure periods was compared with that during the non-exposure period. Beers Criteria were used to define PIMs in patients with dementia. Negative binomial regression was conducted. The incidence rate ratio (IRR) was used to determine the risk of falls or fall-related injuries.
resultsDuring the exposure periods in which falls or fall-related injuries occurred, the mean number of PIMs among patients with dementia was 3.76 (SD = 2.99), and the most commonly used PIMs among patients with dementia were first-generation antihistamines (n = 283; 59.1%). Compared to the non-exposure period, the adjusted IRR during the exposure period was 1.57 (95% CI = 1.39-1.76). The risk of falls or fall-related injuries was increased when PIM use in patients with dementia was initiated (1-14 days: IRR = 2.76, 95% CI = 2.31-3.28; 15-28 days: IRR = 1.95, 95% CI = 1.48-2.56; ≥ 29 days: IRR = 1.17, 95% CI = 1.01-1.35). Especially, an increased risk of falls or fall-related injuries was associated with greater PIM use among patients with dementia.
conclusionAmong older adults with dementia, PIMs significantly increase the risk of falls and fall-related injuries. Therefore, strategies should be developed to manage PIM prescriptions in patients with dementia to prevent falls.
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