Evidence map›Paper›PMID 39179934›Full record

ArticleNature immunology2024

Clonal succession after prolonged antiretroviral therapy rejuvenates CD8

Eoghann White, Laura Papagno, Assia Samri, Kenji Sugata, Boris Hejblum, Amy R Henry, Daniel C Rogan, Samuel Darko, Patricia Recordon-Pinson, Yasmine Dudoit and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Renaissance of antiviral CD8Nature reviews. Immunology · 2026
    Review
  3. Review
  4. CD8Nature · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. CD8medRxiv : the preprint server for health sciences · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Eoghann WhiteImmunoConcEpT, UMR 5164, Université de Bordeaux, CNRS, INSERM, Bordeaux, France.
Laura PapagnoImmunoConcEpT, UMR 5164, Université de Bordeaux, CNRS, INSERM, Bordeaux, France.
Assia SamriCentre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, INSERM, Paris, France.
Kenji SugataDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Boris HejblumBordeaux Population Health Research Centre, U1219, Université de Bordeaux, INSERM, Inria SISTM, Bordeaux, France.ORCID http://orcid.org/0000-0003-0646-452X
Amy R HenryHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Daniel C RoganLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9766-4166
Samuel DarkoHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Patricia Recordon-PinsonMicrobiologie Fondamentale et Pathogénicité, UMR 5234, Université de Bordeaux, CNRS, Bordeaux, France.
Yasmine DudoitInstitut Pierre Louis d'Epidémiologie et de Sante Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Infectious Diseases, Sorbonne Université, INSERM, Paris, France.
Sian Llewellyn-LaceyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Lisa A ChakrabartiCIVIC Group, Virus and Immunity Unit, Institut Pasteur, CNRS UMR 3569, Université Paris Cité, Paris, France.
Florence BuseyneUnité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, CNRS UMR 3569, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-9323-7837
Stephen A MiguelesLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6062-8022
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0001-9416-2737
Marie-Aline AndreolaMicrobiologie Fondamentale et Pathogénicité, UMR 5234, Université de Bordeaux, CNRS, Bordeaux, France.
Yorifumi SatouDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-1495-7810
Rodolphe ThiebautBordeaux Population Health Research Centre, U1219, Université de Bordeaux, INSERM, Inria SISTM, Bordeaux, France.
Christine KatlamaInstitut Pierre Louis d'Epidémiologie et de Sante Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Infectious Diseases, Sorbonne Université, INSERM, Paris, France.
Brigitte AutranCentre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, INSERM, Paris, France.
Daniel C DouekHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5575-8634
Victor AppayImmunoConcEpT, UMR 5164, Université de Bordeaux, CNRS, INSERM, Bordeaux, France. victor.appay@immuconcept.org.ORCID http://orcid.org/0000-0001-5434-3963

Funding

Agence Nationale de la Recherche (French National Research Agency) 14CE16002901Agence Nationale de Recherches sur le Sida et les Hépatites Virales (National Agency for AIDS Research) 2016-A00400-51Japan Agency for Medical Research and Development (AMED) JP22fk0410052Université de Bordeaux (University of Bordeaux) Senior IdEx ChairWellcome Trust (Wellcome) 100326/Z/12/Z
6 · The paper itself

Abstract

Human immunodeficiency virus 1 (HIV-1) infection is characterized by a dynamic and persistent state of viral replication that overwhelms the host immune system in the absence of antiretroviral therapy (ART). The impact of prolonged treatment on the antiviral efficacy of HIV-1-specific CD8

Indexed as

CD8-Positive T-LymphocytesHIV-1HIV InfectionsVirus ReplicationAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCell DifferentiationFemaleHumansMaleMiddle AgedSingle-Cell AnalysisAnti-Retroviral Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.