ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024
Antifungal activity of tannic acid against Candida spp. and its mechanism of action.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Duloxetine repositioning: Investigation of antifungal and antibiofilm activity against fluconazole-sensitive and resistant Candida Spp. strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Antimicrobial Properties of Freeze-Dried Hyaluronic Acid Sheets Containing Persimmon Tannin.International journal of molecular sciences · 2026Article
- Comparative effects of tannic acid and ZnO nanoparticles on hydration, microstructure, and antimicrobial performance of Portland cement.RSC advances · 2026Article
- Tannic acid shaped microbiome composition in midguts and rearing microcosms ofFrontiers in microbiology · 2026Article
- Plant-Derived Modifiers for Antimicrobial Soft Denture Liners: A Review.International journal of molecular sciences · 2025Review
- Tannic Acid Shaped Microbiome Composition in Midguts and Rearing Microcosms ofResearch square · 2025Article
- Antibacterial and Antifungal Tannic Acid Coating on Plasma-Activated Titanium Alloy Surface.International journal of molecular sciences · 2025Article
- Electrospun Nanofibers of Polyvinylidene Fluoride Enriched with Active Antimicrobial Tannic Acid for the Improvement of the Shelf Life of Cherry Tomatoes.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase in fungal resistance is a major public health concern. In this context, Candida spp. is an important genus related to invasive diseases, especially in immunosuppressed patients. The relevance of alternative approaches to increasing fungal resistance stands out, in which products of natural origin demonstrate potential antifungal activity in vitro against Candida spp. In this sense, this work aimed to evaluate the in vitro activity of tannic acid against Candida spp. Minimum inhibitory concentration (MIC) was determined for tannic acid and the antifungals, and the checkerboard assay was performed to analyze the interactions between them. Furthermore, we evaluated the tannic acid antibiofilm activity and its possible mechanism of action. Tannic acid showed MIC ranging to 0.06 to 0.5 µg/ml and showed no loss of effectiveness when combined with antifungals. Also, is safe at the concentrations it exerts its antifungal activity in pre-formed biofilms, as demonstrated by IC50 in murine fibroblasts cells and the hemolytic assay. Additionally, its mechanisms of action can be related with induction of signals that lead to apoptosis in fungal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.