Evidence map›Paper›PMID 39179659›Full record

ReviewNature reviews. Clinical oncology2024

Precision therapeutics and emerging strategies for HR-positive metastatic breast cancer.

Maxwell R Lloyd, Komal Jhaveri, Kevin Kalinsky, Aditya Bardia, Seth A Wander

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Head-to-Head comparison of [European journal of nuclear medicine and molecular imaging · 2025
    Pooled it
  2. Review
  3. Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  8. Turmoil and breakthroughs: Highlights and growing pains in breast cancer therapy 2025Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
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  15. Article
  16. Clinical and Genomic Factors Associated with Elacestrant Outcomes in ESR1-Mutant Metastatic Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maxwell R LloydBeth Israel Deaconess Medical Center, Boston, MA, USA.
Komal JhaveriMemorial Sloan Kettering Evelyn H. Lauder Breast Center, New York, NY, USA.
Kevin KalinskyWinship Cancer Institute at Emory University, Atlanta, GA, USA.
Aditya BardiaUCLA Health Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Seth A WanderMassachusetts General Hospital Cancer Center, Boston, MA, USA. swander@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-4127-4708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-oestrogen-based therapies, often combined with a CDK4/6 inhibitor, are the current standard-of-care first-line therapy for patients with advanced-stage hormone receptor-positive (HR

Indexed as

Breast NeoplasmsPrecision MedicineFemaleHumansMolecular Targeted TherapyNeoplasm MetastasisReceptors, EstrogenReceptors, Estrogen

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.