Evidence map›Paper›PMID 39179609›Full record

ArticleNPJ Parkinson's disease2024

Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats.

Natosha M Mercado, Carlye Szarowicz, Jennifer A Stancati, Caryl E Sortwell, Samuel A Boezwinkle, Timothy J Collier, Margaret E Caulfield, Kathy Steece-Collier

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In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Natosha M Mercado *Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Carlye Szarowicz *Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0002-3972-2161
Jennifer A StancatiDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Caryl E SortwellDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Samuel A BoezwinkleCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Timothy J CollierDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Margaret E CaulfieldDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0002-9433-0881
Kathy Steece-CollierDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA. kathy.steececollier@gmail.com.ORCID http://orcid.org/0000-0002-8137-2310

Funding

Impact of Dysfunctional BDNF on Dopamine Terminal Remodeling in the Parkinsonian StriatumR01NS105826 · NINDS · MICHIGAN STATE UNIVERSITY · PI STEECE-COLLIER, KATHY · 2019 to 2023
$1.8M
NINDS NIH HHS R01 NS105826U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS105826
6 · The paper itself

Abstract

The rs6265 single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor is a common variant that alters therapeutic outcomes for individuals with Parkinson's disease (PD). We previously investigated the effects of this SNP on the experimental therapeutic approach of neural grafting, demonstrating that young adult parkinsonian rats carrying the variant Met allele exhibited enhanced graft function compared to wild-type rats and also exclusively developed aberrant graft-induced dyskinesias (GID). Aging is the primary risk factor for PD and reduces graft efficacy. Here we investigated whether aging interacts with this SNP to further alter cell transplantation outcomes. We hypothesized that aging would reduce enhancement of graft function associated with this genetic variant and exacerbate GID in all grafted subjects. Unexpectedly, beneficial graft function was maintained in aged rs6265 subjects. However, aging was permissive to GID induction, regardless of genotype, with the greatest incidence and severity found in rs6265-expressing animals.

Identifiers

PMID39179609
PMCPMC11344059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.