ArticleNature communications2024
Relating sex-bias in human cortical and hippocampal microstructure to sex hormones.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regional sex differences in human cortical anatomy vary in their morphometric bases and overlap with sex chromosomal and gonadal influences.Nature communications · 2026Article
- The cellular correlates and adolescent reorganisation of cortical myelination networks in the common marmoset.Communications biology · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- The influence of sample size and covariate distributions on neuroanatomical normative modeling.eLife · 2026Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Tensor dictionary-based heterogeneous transfer learning to study emotion-related gender differences in brain.Neural networks : the official journal of the International Neural Network Society · 2025Article
- Disparities in accelerated brain aging in recent-onset and chronic schizophrenia.Psychological medicine · 2025Article
- Exploring neuroendocrine influences on the sensorimotor-association axis in a female and a male individual.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Intracortical microstructure profiling: A cross-modal method for indexing cortical lamination.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment of brain-related disorders. So far, studies on sex-bias in brain structure predominantly focus on macro-scale measures, and often ignore factors determining this bias. Here we study sex-bias in cortical and hippocampal microstructure in relation to sex hormones. Investigating quantitative intracortical profiling in-vivo using the T1w/T2w ratio in 1093 healthy females and males of the cross-sectional Human Connectome Project young adult sample, we find that regional cortical and hippocampal microstructure differs between males and females and that the effect size of this sex-bias varies depending on self-reported hormonal status in females. Microstructural sex-bias and expression of sex hormone genes, based on an independent post-mortem sample, are spatially coupled. Lastly, sex-bias is most pronounced in paralimbic areas, with low laminar complexity, which are predicted to be most plastic based on their cytoarchitectural properties. Albeit correlative, our study underscores the importance of incorporating sex hormone variables into the investigation of brain structure and plasticity.
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