ArticleNature communications2024
Transovarial transmission of Yersinia pestis in its flea vector Xenopsylla cheopis.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Environmental and Host Blood Interactions ShapePathogens (Basel, Switzerland) · 2026Article
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- Review
- Interaction of Bacteria and Fleas, Focusing on the Plague Bacterium-A Review.Microorganisms · 2025Review
- Spatial and temporal characterisation of genetic and phenotypic properties of Yersinia pestis in Kazakhstan's natural plague foci.Environmental analysis, health and toxicology · 2025Article
- Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar.PLoS neglected tropical diseases · 2025Article
- A decade of research on ectoparasites and endoparasites in wild rats in Indonesia (2015-2025): A review.Open veterinary journal · 2025Review
- Transovarial transmission of Yersinia pestis in its flea vector, Xenopsylla cheopis.Research square · 2023Article
Corrections and comments
- Update of
Authors and funding
4 authors.
Funding
Abstract
Yersinia pestis, the causative agent of plague, is endemic in certain regions due to a stable transmission cycle between rodents and their associated fleas. In addition, fleas are believed to serve as reservoirs that can occasionally cause enzootic plague cycles and explosive epizootic outbreaks that increase human exposure. However, transmission by fleas is inefficient and associated with a shortened lifespan of the flea and rodent hosts, indicating that there remain significant gaps in our understanding of the vector-animal cycle of Y. pestis. Here, we show that laboratory-reared, infected fleas (Xenopsylla cheopis) can transmit viable Y. pestis from adults to eggs, and the bacteria can be passed through all subsequent life stages of the flea. Thus, our data raise the possibility that transovarial transmission in fleas might contribute to the persistence of Y. pestis in the environment without detectable plague activity in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.