Evidence map›Paper›PMID 39179433›Full record

ArticleSurgery2024

Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients.

Valerie E Polcz, Evan L Barrios, Michael C Cox, Ivanna Rocha, Muxuan Liang, Russell B Hawkins, Dijoia Darden, Ricardo Ungaro, Marvin Dirain, Robert Mankowski and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valerie E PolczDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL. Electronic address: https://www.twitter.com/ValeriePolcz.
Evan L BarriosDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Michael C CoxDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Ivanna RochaDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Muxuan LiangDepartment of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL.
Russell B HawkinsDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Dijoia DardenDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Ricardo UngaroDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Marvin DirainDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Robert MankowskiDivision of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama, Birmingham, AL.
Alicia M MohrDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Frederick A MooreDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Lyle L MoldawerDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Philip A EfronDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL.
Scott C BrakenridgeDepartment of Surgery, College of Medicine, University of Washington, Harborview Medical Center, Seattle, WA.
Tyler J LoftusDepartment of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL. Electronic address: tyler.loftus@surgery.ufl.edu.

Funding

Renewal: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis PathobiologyRM1GM139690 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron, Michael Paul Kladde · 2021 to 2026
$10.3M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
R35 Equipment SupplementR35GM140806 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2021 to 2025
$2.2M
Immunological Endotyping of Chronic Critical Illness after Severe Trauma or Sepsis: Administrative SupplementR35GM142481 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRAKENRIDGE, SCOTT CHARLES · 2021 to 2025
$2.0M
Understanding pathology of sepsis-induced physical disability for future precision medicine.R35GM151038 · NIGMS · UNIVERSITY OF FLORIDA · PI Robert T Mankowski · 2023 to 2026
$1.4M
Aligning Patient Acuity with Resource Intensity after Major SurgeryR01GM149657 · NIGMS · UNIVERSITY OF FLORIDA · PI Tyler J Loftus · 2023 to 2026
$1.3M
Aligning Patient Acuity with Intensity of Care after SurgeryK23GM140268 · NIGMS · UNIVERSITY OF FLORIDA · PI LOFTUS, TYLER J · 2020 to 2023
$619k
NIGMS NIH HHS K23 GM140268NIGMS NIH HHS R01 GM149657NIGMS NIH HHS R35 GM140806NIGMS NIH HHS R35 GM142481NIGMS NIH HHS R35 GM151038NIGMS NIH HHS RM1 GM139690NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

introductionSarcopenia is a known risk factor for adverse outcomes across multiple disease states, including severe trauma. Factors such as age, hyperinflammation, prolonged immobilization, and critical illness may not only exacerbate progression of this disease but may also contribute to the development of induced sarcopenia, or sarcopenia secondary to hospitalization. This study seeks to (1) determine the effects of severe traumatic injury on changes in skeletal muscle mass in older adults; (2) test whether changes in skeletal muscle mass are associated with clinical frailty, physical performance, and health-related quality of life; and (3) examine trauma-induced frailty and temporal changes in myokine and chemokine profiles.

methodsA prospective, longitudinal cohort study of 47 critically ill, older (≥45 years) adults presenting after severe blunt trauma was conducted. Repeated measures of computed tomography-based skeletal muscle index, frailty, and quality of life were obtained in addition to selected plasma biomarkers over 6 months.

resultsSevere trauma was associated with significant losses in skeletal muscle mass and increased incidence of sarcopenia from 36% at baseline to 60% at 6 months. Severe trauma also was associated with a transient worsening of induced frailty and reduced quality of life irrespective of sarcopenia status, which returned to baseline by 6 months after injury. Admission biomarker levels were not associated with skeletal muscle index at the time points studied but demonstrated distinct temporal changes across our entire cohort.

conclusionsSevere blunt trauma in older adults is associated with increased incidence of induced sarcopenia and reversible induced frailty. Despite muscle wasting, functional decline is transient, with a return to baseline by 6 months, suggesting a need for holistic definitions of sarcopenia and further investigation into long-term functional outcomes in this population.

Indexed as

FrailtyMuscle, SkeletalQuality of LifeSarcopeniaAgedAged, 80 and overBiomarkersChemokinesCritical IllnessFemaleHumansLongitudinal StudiesMaleMiddle AgedMyokinesProspective StudiesBiomarkersChemokinesMyokines

Identifiers

PMID39179433
PMCPMC11931520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.