Evidence map›Paper›PMID 39179416›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2024

Gabapentinoids Increase the Potency of Fentanyl and Heroin and Decrease the Potency of Naloxone to Antagonize Fentanyl and Heroin in Rats Discriminating Fentanyl.

Takato Hiranita, Shawn M Flynn, Amanda K Grisham, Abram E Mijares, Erin N Murphy, Charles P France

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takato HiranitaDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas hiranita@uthscsa.edu.
Shawn M FlynnDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Amanda K GrishamDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Abram E MijaresDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Erin N MurphyDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Charles P FranceDepartments of Pharmacology (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.) and Psychiatry (C.P.F.) and Addiction Research, Treatment & Training Center of Excellence (T.H., S.M.F., A.K.G., A.E.M., E.N.M., C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Funding

Gabapentinoid/opioid mixtures: abuse and toxicityR01DA058018 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Takato Hiranita · 2023 to 2026
$1.7M
Reversal of ventilatory depression by drug mixturesF31DA057832 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FLYNN, SHAWN MICHAEL · 2023 to 2024
$75k
NIDA NIH HHS F31 DA057832NIDA NIH HHS R01 DA058018
6 · The paper itself

Abstract

Despite a significant decrease in the number of prescriptions for opioids, the opioid crisis continues, fueled in large part by the availability of the phenylpiperidine

Indexed as

FentanylGabapentinHeroinNaloxoneRats, Sprague-DawleyAnimalsDose-Response Relationship, DrugFemaleMaleNarcotic AntagonistsPregabalinRatsFentanylGabapentinHeroinNaloxoneNarcotic AntagonistsPregabalin

Identifiers

PMID39179416
PMCPMC11493450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.