Evidence map›Paper›PMID 39179319›Full record

ArticleJournal, genetic engineering & biotechnology2024

Can human IgG subclasses distinguish between confirmed and unconfirmed SARS-CoV-2 infections?

Mahmoud Mohamed Bahgat, Mohamed Hassan Nasraa, Rola Nadeem, Khaled Amer, Wael A Hassan, Ahmed Abd El-Raouf, Dina Nadeem Abd-Elshafy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahmoud Mohamed BahgatResearch Group Immune- and Bio-markers for Infection, the Center of Excellent for Advanced Science, The National Research Centre, 12622 Cairo, Egypt; Department of Therapeutic Chemistry, Institute of Pharmaceutical and Drug Industries Research, The National Research Centre, 12622 Cairo, Egypt. Electronic address: mbahgatriad@yahoo.com.
Mohamed Hassan NasraaResearch Group Immune- and Bio-markers for Infection, the Center of Excellent for Advanced Science, The National Research Centre, 12622 Cairo, Egypt; Department of Therapeutic Chemistry, Institute of Pharmaceutical and Drug Industries Research, The National Research Centre, 12622 Cairo, Egypt. Electronic address: mm.riad@nrc.sci.eg.
Rola NadeemResearch Group Immune- and Bio-markers for Infection, the Center of Excellent for Advanced Science, The National Research Centre, 12622 Cairo, Egypt; Department of Therapeutic Chemistry, Institute of Pharmaceutical and Drug Industries Research, The National Research Centre, 12622 Cairo, Egypt.
Khaled AmerEgypt Center for Research and Regenerative Medicine, Cairo, Egypt.
Wael A HassanEgypt Center for Research and Regenerative Medicine, Cairo, Egypt.
Ahmed Abd El-RaoufEgypt Center for Research and Regenerative Medicine, Cairo, Egypt.
Dina Nadeem Abd-ElshafyResearch Group Immune- and Bio-markers for Infection, the Center of Excellent for Advanced Science, The National Research Centre, 12622 Cairo, Egypt; Environmental Virology Laboratory, Department of Water Pollution Research, Institute of Environmental Research and Climate Changes, the National Research Centre, 12622 Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunoglobulin G (IgG) subclasses play a crucial role in the immune response to viral infections. While total IgG levels can generally provide an indication on the immune response, specific IgG subclasses can offer more detailed information about nature of the immune response and stage of the infection. Herein, we addressed the value of both total (t) and SARS-CoV-2-specific (s) IgG-subclasses in distinguishing between infection-confirmed virus-qRT-PCR-positive (IC; V-qRT-PCR-P) and infection-unconfirmed virus-qRT-PCR-unchecked (IU; V-qRT-PCR-UC) Egyptians.

resultsBoth the t-IgG2 and 4 means were significantly higher (SH) among the IU subjects, whereas, the s-IgG1 and 3 means were SH among the IC ones. On the gender levels, both the t-IgG2 and 4 means were SH among the IU females, whereas, the mean of the s-IgG1 was SH among the IC females. The t-IgG4 mean was SH among the IU males, whereas, both means of the s-IgG1 and 3 were SH among the IC males. Significant positive correlations (SPC) were recorded between both the t-IgG1 and 3 with the symptom grades (SG) among the IU humans (r

conclusionAlthough the limitation of the small studied sample size, our results suggest some total and SARS-CoV-2-specific IgG-subclasses as both supplemental and gender-specific immune markers to distinguish between confirmed and unconfirmed SARS-CoV-2 infections.

Indexed as

Infection-confirmedInfection-unconfirmedTotal and SARS-CoV-2-specific IgG subclassesVirus-qRT-PCR-positiveVirus-qRT-PCR-unchecked

Identifiers

PMID39179319
PMCPMC11345650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.