Evidence map›Paper›PMID 39179297›Full record

ReviewAJNR. American journal of neuroradiology2025

Alzheimer Disease Anti-Amyloid Immunotherapies: Imaging Recommendations and Practice Considerations for Monitoring of Amyloid-Related Imaging Abnormalities.

Petrice M Cogswell, Trevor J Andrews, Jerome A Barakos, Frederik Barkhof, Suzie Bash, Marc Daniel Benayoun, Gloria C Chiang, Ana M Franceschi, Clifford R Jack, Jay J Pillai and 11 more

Abstract readReview
In one paragraph

Review in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Trial
  4. Article
  5. Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer's Disease: an Italian RAND/UCLA consensus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  6. Article
  7. Article
  8. Amyloid-beta-targeting monoclonal antibodies in early Alzheimer's disease: a cochrane review summary and appraisal for the neurological community.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Lecanemab use in Chinese patients with Alzheimer's disease: a 12-month multicenter real-world study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Observational
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Petrice M CogswellFrom the Department of Radiology (P.M.C., C.R.J., J.J.P.), Mayo Clinic, Rochester, Minnesota Cogswell.petrice@mayo.edu.ORCID https://orcid.org/0000-0002-8128-4476
Trevor J AndrewsDepartment of Radiology (T.J.A., C.A.R., T.S.B.), Washington University School of Medicine, St. Louis, Missouri.
Jerome A BarakosDepartment of Radiology (J.A.B.), California Pacific Medical Center, San Francisco, California.
Frederik BarkhofDepartment of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands.
Suzie BashRadNet Imaging Centers (S.B., L.T.), Los Angeles, California.ORCID https://orcid.org/0000-0002-2572-1010
Marc Daniel BenayounDepartments of Radiology (M.D.B., C.T.W.), Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0002-0337-517X
Gloria C ChiangDepartment of Radiology (G.C.C.), Weill Cornell Imaging and New York Presbyterian, New York, New York.ORCID https://orcid.org/0000-0001-9925-0816
Ana M FranceschiDepartment of Radiology (A.M.F.), Northwell Health, New York, New York.ORCID https://orcid.org/0000-0003-2577-9738
Clifford R JackFrom the Department of Radiology (P.M.C., C.R.J., J.J.P.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0001-7916-622X
Jay J PillaiFrom the Department of Radiology (P.M.C., C.R.J., J.J.P.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-8306-7192
Tina Young PoussaintDepartment of Radiology (T.Y.P.), Boston Children's Hospital, Boston, Massachusetts.
Cyrus A RajiDepartment of Radiology (T.J.A., C.A.R., T.S.B.), Washington University School of Medicine, St. Louis, Missouri.ORCID https://orcid.org/0000-0002-9086-0105
Vijay K RamananDepartment of Neurology (V.K.R.), Mayo Clinic, Rochester, Minnesota.
Jody TanabeUC Health (J.T.), University of Colorado Hospital, Aurora, Colorado.ORCID https://orcid.org/0000-0002-7110-8444
Lawrence TanenbaumRadNet Imaging Centers (S.B., L.T.), Los Angeles, California.ORCID https://orcid.org/0000-0003-3326-3192
Christopher T WhitlowDepartments of Radiology (M.D.B., C.T.W.), Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0003-2392-8293
Fang F YuDepartment of Radiology (F.F.Y.), Utah Southwestern Medical Center, Dallas, Texas.ORCID https://orcid.org/0000-0001-9913-1331
Greg ZaharchukDepartment of Radiology (G.Z., M.Z.), Stanford Health Care, Stanford Medicine Children's Hospital, Stanford, California.ORCID https://orcid.org/0000-0001-5781-8848
Michael ZeinahDepartment of Radiology (G.Z., M.Z.), Stanford Health Care, Stanford Medicine Children's Hospital, Stanford, California.
ASNR Alzheimer, ARIA, and Dementia Study Group

Funding

DIAN-TU: Tau Next Generation Prevention Trial - Administrative SupplementR01AG068319 · NIA · WASHINGTON UNIVERSITY · PI RANDALL J BATEMAN · 2020 to 2026
$81.4M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
DIAN-TU Next Generation Prevention Trial - Data Request Management SupplementR01AG053267 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2017 to 2023
$34.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
Dominantly Inherited Alzheimer's Network Trials Unit - Adaptive Prevention TrialR01AG046179 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2019
$26.6M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Dominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6M
DOMINANTLY INHERITED ALZHEIMER NETWORK TRIAL: AN OPPORTUNITY TO PREVENT DEMENTIAU01AG042791 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2013 to 2018
$8.9M
DIAN-TU: Next Generation Prevention TrialR56AG053267 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2016 to 2016
$3.2M
NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG046179NIA NIH HHS R01 AG053267NIA NIH HHS R01 AG068319NIA NIH HHS R56 AG053267NIA NIH HHS U01 AG042791NIA NIH HHS U19 AG032438NIA NIH HHS UF1 AG032438
6 · The paper itself

Abstract

With full FDA approval and Centers for Medicare & Medicaid Services coverage of lecanemab and donanemab, a growing number of practices are offering anti-amyloid immunotherapy to appropriate patients with cognitive impairment or mild dementia due to amyloid-positive Alzheimer disease. The goal of this article is to provide updated practical considerations for radiologists, including implementation of MR imaging protocols, workflows, and reporting and communication practices relevant to anti-amyloid immunotherapy and monitoring for amyloid-related imaging abnormalities (ARIA). On the basis of consensus discussion within an expanded American Society of Neuroradiology (ASNR) Alzheimer, ARIA, and Dementia Study Group, our purpose is the following: 1) summarize the FDA guidelines for the evaluation of radiographic ARIA; 2) review the 3 key MRI sequences for ARIA monitoring and standardized imaging protocols on the basis of ASNR-industry collaborations; 3) provide imaging recommendations for 3 key patient scenarios; 4) highlight the role of the radiologist in the care team for this population; 5) discuss implementation of MRI protocols to detect ARIA in diverse practice settings; and 6) present the results of the 2023 ASNR international neuroradiologist practice survey on dementia and ARIA imaging.

Indexed as

Alzheimer DiseaseAmyloidImmunotherapyNeuroimagingPractice Guidelines as TopicAntibodies, Monoclonal, HumanizedHumansMagnetic Resonance ImagingAmyloidAntibodies, Monoclonal, Humanized

Identifiers

PMID39179297
PMCPMC11735439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.