Evidence map›Paper›PMID 39179169›Full record

ArticleExperimental eye research2024

MitoQ relieves mitochondrial dysfunction in UVA and cigarette smoke-induced Fuchs endothelial corneal dystrophy.

Sean T Bannon, Nathan Shatz, Raymond Wong, Mohit Parekh, Ula V Jurkunas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sean T BannonSchepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA, USA.
Nathan ShatzSchepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Raymond WongSchepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Mohit ParekhSchepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Ula V JurkunasSchepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address: ula_jurkunas@meei.harvard.edu.

Funding

The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal DysR01EY020581 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Ula V. Jurkunas · 2010 to 2026
$8.0M
NEI NIH HHS R01 EY020581
6 · The paper itself

Abstract

Fuchs endothelial corneal dystrophy (FECD), a degenerative corneal condition, is characterized by the droplet-like accumulation of the extracellular matrix, known as guttae and progressive loss of corneal endothelial cells ultimately leading to visual distortion and glare. FECD can be influenced by environmental stressors and genetic conditions. However, the role of mitochondrial dysfunction for advancing FECD pathogenesis is not yet fully studied. Therefore, in the present study we sought to determine whether a combination of environmental stressors (ultraviolet-A (UVA) light and cigarette smoke condensate (CSC)) can induce mitochondrial dysfunction leading to FECD. We also investigated if MitoQ, a water-soluble antioxidant, can target mitochondrial dysfunction induced by UVA and CSC in human corneal endothelial cells mitigating FECD pathogenesis. We modeled the FECD by increasing exogenous oxidative stress with CSC (0.2%), UVA (25J/cm

Indexed as

AntioxidantsFuchs' Endothelial DystrophyMitochondriaOrganophosphorus CompoundsOxidative StressUbiquinoneUltraviolet RaysApoptosisCells, CulturedCell SurvivalEndothelium, CornealHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesSmokeAntioxidantsmitoquinoneOrganophosphorus CompoundsReactive Oxygen SpeciesSmokeUbiquinoneCorneaCorneal endotheliumEyeFuchs endothelial corneal dystrophyMitochondriaMitoQ

Identifiers

PMID39179169
PMCPMC11426332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.