Evidence map›Paper›PMID 39178923›Full record

ArticleFree radical biology & medicine2024

Mitochondrial free radicals contribute to cigarette smoke condensate-induced impairment of oxidative phosphorylation in the skeletal muscle in situ.

Sean T Bannon, Stephen T Decker, Muhammet Enes Erol, Rong Fan, Yu-Ting Huang, Soonkyu Chung, Gwenael Layec

Abstract read
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In one paragraph

Article in Free radical biology & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sean T BannonDepartment of Kinesiology, University of Massachusetts Amherst, MA, USA.
Stephen T DeckerDepartment of Kinesiology, University of Massachusetts Amherst, MA, USA; Diabetes and Metabolism Research Center, University of Utah, UT, USA.
Muhammet Enes ErolDepartment of Kinesiology, University of Massachusetts Amherst, MA, USA; School of Health and Kinesiology, University of Nebraska Omaha, NE, USA.
Rong FanDepartment of Nutrition, University of Massachusetts Amherst, MA, USA.
Yu-Ting HuangDepartment of Kinesiology, University of Massachusetts Amherst, MA, USA.
Soonkyu ChungDepartment of Nutrition, University of Massachusetts Amherst, MA, USA.
Gwenael LayecDepartment of Kinesiology, University of Massachusetts Amherst, MA, USA; School of Health and Kinesiology, University of Nebraska Omaha, NE, USA. Electronic address: glayec@unomaha.edu.

Funding

Nitric oxide coupling and BH4 availability roles in muscle dysfunction with COPDR00HL125756 · NHLBI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LAYEC, GWENAEL · 2018 to 2020
$738k
NHLBI NIH HHS R00 HL125756
6 · The paper itself

Abstract

Oxidative stress plays a critical role in cellular dysfunction associated with cigarette smoke exposure and aging. Some chemicals from tobacco smoke have the potential to amplify mitochondrial ROS (mROS) production, which, in turn, may impair mitochondrial respiratory function. Accordingly, the present study tested the hypothesis that a mitochondria-targeted antioxidant (MitoTEMPO, MT) would attenuate the inhibitory effects of cigarette smoke on skeletal muscle respiratory capacity of middle-aged mice. Specifically, mitochondrial oxidative phosphorylation was assessed using high-resolution respirometry in permeabilized fibers from the fast-twitch gastrocnemius muscle of middle-aged C57Bl/6J mice. Before the assessment of respiration, tissues were incubated for 1hr with a control buffer (CON), cigarette smoke condensate (2 % dilution, SMOKE), or MitoTEMPO (10 μM) combined with cigarette smoke condensate (MT + SMOKE). Cigarette smoke condensate (CSC) decreased maximal-ADP stimulated respiration (CON: 60 ± 15 pmolO

Indexed as

Free RadicalsMitochondria, MuscleMuscle, SkeletalOxidative PhosphorylationSmokeTobacco ProductsAnimalsAntioxidantsCell RespirationFemaleGlutamic AcidMaleMiceMice, Inbred C57BLOrganophosphorus CompoundsOxidative StressAntioxidantsFree RadicalsGlutamic AcidMitoTEMPOOrganophosphorus CompoundsPiperidinesSmokeAgingCigarette smokeHigh-resolution respirometryMito-TEMPORedox stressSkeletal muscle

Identifiers

PMID39178923
PMCPMC11975403

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.