Evidence map›Paper›PMID 39178916›Full record

ArticleAutophagy2025

USP8 promotes intracellular infection by enhancing ESCRT-mediated membrane repair, limiting xenophagy, and reducing oxidative stress.

Pallavi Chandra, Jennifer A Philips

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pallavi ChandraDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6301-7617
Jennifer A PhilipsDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9476-0240

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Mechanisms of Innate Immune Evasion by Mycobacterium TuberculosisR01AI130454 · NIAID · WASHINGTON UNIVERSITY · PI JENNIFER A PHILIPS · 2017 to 2026
$5.9M
THE ROLE OF ESCRT IN MACROPHAGE RESISTANCE TO MYCOBACTERIAR01AI087682 · NIAID · WASHINGTON UNIVERSITY · PI PHILIPS, JENNIFER A · 2011 to 2022
$4.9M
ZEISS LSM880 AIRYSCAN MICROSCOPE FOR SHARED BIOMEDICAL RESEARCHS10OD021629 · OD · WASHINGTON UNIVERSITY · PI FITZPATRICK, JAMES ALEXANDER · 2017 to 2017
$596k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI087682NIAID NIH HHS R01 AI130454NIH HHS S10 OD021629
6 · The paper itself

Abstract

The host ESCRT-machinery repairs damaged endolysosomal membranes. If damage persists, selective macroautophagy/autophagy clears the damaged compartment.

Indexed as

AutophagyEndopeptidasesEndosomal Sorting Complexes Required for TransportMacroautophagyMycobacterium tuberculosisOxidative StressUbiquitin ThiolesteraseAnimalsHumansMacrophagesMiceMice, Inbred C57BLNF-E2-Related Factor 2PhagosomesUbiquitinationEndopeptidasesEndosomal Sorting Complexes Required for TransportNF-E2-Related Factor 2Ubiquitin ThiolesteraseAutophagydeubiquitinaseendomembrane damageMycobacterium tuberculosisoxidative stress

Identifiers

PMID39178916
PMCPMC11759523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.