Evidence map›Paper›PMID 39178853›Full record

ArticleCell2024

Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration.

Daniel R Hochbaum, Lauren Hulshof, Amanda Urke, Wengang Wang, Alexandra C Dubinsky, Hannah C Farnsworth, Richard Hakim, Sherry Lin, Giona Kleinberg, Keiramarie Robertson and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Review
  9. Article
  10. bioRxiv : the preprint server for biology · 2026
    Article
  11. Transcriptomic and Neuroimaging Decoding of Brain-Immune Crosstalk in Thyroid Eye Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Article
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  14. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Daniel R HochbaumHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Society of Fellows, Harvard University, Cambridge, MA 02138, USA.
Lauren HulshofHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Amanda UrkeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Wengang WangHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Alexandra C DubinskyHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Hannah C FarnsworthHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Richard HakimHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Sherry LinDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Giona KleinbergHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Keiramarie RobertsonHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Canaria ParkHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Alyssa SolbergHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Yechan YangHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Caroline BaynardHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Naeem M NadafBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Celia C BeronHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Allison E GirasoleHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Lynne ChantranupongHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Marissa D CortopassiDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Shannon ProutyDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Ludwig GeistlingerCenter for Computational Biomedicine, Harvard Medical School, Boston, MA 02215, USA.
Alexander S BanksDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Thomas S ScanlanDepartment of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
Sandeep Robert DattaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Michael E GreenbergDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Gabriella L BoultingDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Evan Z MacoskoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bernardo_sabatini@hms.harvard.edu.

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4M
Action and interaction of ionotropic and metabotropic neurotransmissionR37NS046579 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2018 to 2024
$4.6M
Action and Interaction of Neurotransmitters and NeuromodulatorsR35NS137336 · NINDS · HARVARD MEDICAL SCHOOL · PI Bernardo L Sabatini · 2024 to 2026
$2.1M
CalRepository: A database of indirect calorimetry experiments for the study of energy homeostasisR01DK133948 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2022 to 2025
$2.0M
Instrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737k
NICHD NIH HHS P50 HD105351NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK133948NIGMS NIH HHS T32 GM144273NIH HHS S10 OD028635NINDS NIH HHS R35 NS137336NINDS NIH HHS R37 NS046579
6 · The paper itself

Abstract

Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we find that thyroid hormone-a regulator of metabolism in many peripheral organs-directly activates cell-type-specific transcriptional programs in the frontal cortex of adult male mice. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulatory genes in both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread plasticity of cortical circuits. Indeed, whole-cell electrophysiology revealed that thyroid hormone alters excitatory and inhibitory synaptic transmission, an effect that requires thyroid hormone-induced gene regulatory programs in presynaptic neurons. Furthermore, thyroid hormone action in the frontal cortex regulates innate exploratory behaviors and causally promotes exploratory decision-making. Thus, thyroid hormone acts directly on the cerebral cortex in males to coordinate exploratory behaviors with whole-body metabolic state.

Indexed as

Thyroid HormonesAnimalsAstrocytesCerebral CortexExploratory BehaviorFrontal LobeMaleMiceMice, Inbred C57BLNeuronsOligodendrogliaSynaptic TransmissionThyroid Hormonesbody-brain coordinationexplorationmetabolismneurosciencesynaptic plasticitythyroid hormonetranscriptionally regulated behavior

Identifiers

PMID39178853
PMCPMC11455614

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.