Evidence map›Paper›PMID 39178742›Full record

ArticleEBioMedicine2024

Altered memory CCR6

Alexis Yero, Jean-Philippe Goulet, Tao Shi, Cecilia T Costiniuk, Jean-Pierre Routy, Cecile Tremblay, Ralph-Sydney Mboumba Bouassa, Yulia Alexandrova, Amélie Pagliuzza, Nicolas Chomont and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexis YeroDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada.
Jean-Philippe GouletCellCarta, Montreal, QC, Canada.
Tao ShiDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada.
Cecilia T CostiniukChronic Viral Illness Service and Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Jean-Pierre RoutyChronic Viral Illness Service and Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Cecile TremblayCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montreal, QC, Canada; Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
Ralph-Sydney Mboumba BouassaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada.
Yulia AlexandrovaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada.
Amélie PagliuzzaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montreal, QC, Canada.
Nicolas ChomontCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montreal, QC, Canada; Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
Petronela AncutaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montreal, QC, Canada; Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
Mohammad-Ali JenabianDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada; Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada. Electronic address: jenabian.mohammad-ali@uqam.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6

methodsmRNA-sequencing was performed using Illumina technology on freshly FACS-sorted memory CCR6

findingsDecreased Th17 cell frequencies in STs and ECs versus HDs coincided with reduced Th17-lineage cytokine production in vitro. Accordingly, the RORγt/RORC2 repressor NR1D1 was upregulated, while the RORγt/RORC2 inducer Semaphorin 4D was decreased in memory CCR6

interpretationThese results reveal new molecular mechanisms of Th17 cell deficit in ST and EC PWH despite a successful control of HIV-1 replication. This knowledge points to potential therapeutic interventions to limit HIV-1 infection and restore frequencies, effector functions, and senescence/exhaustion in Th17 cells.

fundingThis study was funded by the Canadian Institutes of Health Research (CIHR, operating grant MOP 142294, and the Canadian HIV Cure Enterprise [CanCURE 2.0] Team Grant HB2 164064), and in part, by the Réseau SIDA et maladies infectieuses du Fonds de recherche du Québec-Santé (FRQ-S).

Indexed as

HIV-1HIV InfectionsImmunologic MemoryReceptors, CCR6Th17 CellsAdultAntiretroviral Therapy, Highly ActiveBiomarkersCytokinesFemaleGene Expression ProfilingHumansMaleMemory T CellsMiddle AgedViral LoadBiomarkersCCR6 protein, humanCytokinesReceptors, CCR6CCR6DNA damageDNA repairHIV infectionHIV persistenceTh17 cellsTranscriptomics

Identifiers

PMID39178742
PMCPMC11388266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.