ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024
Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.
Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise Interventions for Depression, Anxiety, and Quality of Life in Older Adults With Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Cognitive behavioral stress management effects on cancer-related distress and neuroendocrine signaling in breast cancer: differential effects by neighborhood disadvantage.Breast cancer research and treatment · 2025Trial
- Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival.Breast cancer research and treatment · 2026Article
- Neighborhood Opportunity and Genetic Literacy in a Representative Sample of US Adults.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- The impact of social determinants of health on mental and behavioral health trajectories of breast cancer survivors: A longitudinal cohort study.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2026Article
- High-Deductible Health Plans and Mortality Among Cancer Survivors.JAMA network open · 2026Article
- Social genomics and cancer - untangling nature from nurture in squamous cell carcinoma outcomes.Frontiers in oncology · 2026Review
- AI-driven chemotoxicity prediction in colorectal cancer: impact of race, SDOH, and biological aging.BMC cancer · 2025Article
- Community Factors and County-Level Cancer Screening, Prevalence, and Mortality.JAMA network open · 2025Article
- Social Adversity and Triple-Negative Breast Cancer Incidence Among US Black Women.JAMA network open · 2025Article
- Identifying and mitigating the biological effectors of the social determinants of health in cancer.Journal of the National Cancer Institute · 2025Article
- Distinct Sources of Social Adversity, Stress, and Coping Mechanisms among Patients with Breast Cancer to Identify Areas for Intervention.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.Epidemiology and psychiatric sciences · 2025Article
- Socioeconomic status impacts tumor biology, treatment, and outcomes in over 200,000 patients with invasive lobular carcinoma of the breast: an analysis of the National Cancer Database.Breast cancer research and treatment · 2025Article
- Extending catchment area approaches to a community cancer center: a breast cancer hotspot case study.JNCI cancer spectrum · 2025Article
- Exploring the link between adverse childhood experiences and cancer development - insights and intervention recommendations from a scoping review.Npj mental health research · 2025Article
- Genetic Ancestry and 21-Gene Oncotype DX Breast Cancer Recurrence Scores.Annals of surgical oncology · 2025Article
- Geospatial Genomics: Operationalizing Multilevel Conceptual Frameworks of Cancer Health Outcomes to Account for Gene-Person-Place Relationships.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Impact of occupation on survival of esophageal squamous cell carcinoma patients following esophagectomy: a long-term survival analysis.BMC gastroenterology · 2025Article
- A Neighborhood-Level Hispanic Paradox: The Interaction among Hispanic Density, Neighborhood Disadvantage, and Survival in Patients with Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeNeighborhoods represent complex environments with unique social, cultural, physical, and economic attributes that have major impacts on disparities in health, disease, and survival. Neighborhood disadvantage is associated with shorter breast cancer recurrence-free survival (RFS) independent of individual-level (race, ethnicity, socioeconomic status, insurance, tumor characteristics) and health system-level determinants of health (receipt of guideline-concordant treatment). This persistent disparity in RFS suggests unaccounted mechanisms such as more aggressive tumor biology among women living in disadvantaged neighborhoods compared with advantaged neighborhoods. The objective of this article was to provide a clear framework and biological mechanistic explanation for how neighborhood disadvantage affects cancer survival.
methodsDevelopment of a translational epidemiological framework that takes a translational disparities approach to study cancer outcome disparities through the lens of social genomics and social epigenomics.
resultsThe social genomic determinants of health, defined as the physiological gene regulatory pathways (ie, neural/endocrine control of gene expression and epigenetic processes) through which contextual factors, particularly one's neighborhood, can affect activity of the cancer genome and the surrounding tumor microenvironment to alter disease progression and treatment outcomes.
conclusionWe propose a novel, multilevel determinants of health model that takes a translational epidemiological approach to evaluate the interplay between political, health system, social, psychosocial, individual, and social genomic determinants of health to understand social disparities in oncologic outcomes. In doing so, we provide a concrete biological pathway through which the effects of social processes and social epidemiology come to affect the basic biology of cancer and ultimately clinical outcomes and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.