ArticleEuropean journal of preventive cardiology2024
Smoking timing, genetic susceptibility, and the risk of incident atrial fibrillation: a large prospective cohort study.
Article in European journal of preventive cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Time to first cigarette after waking and incident heart failure: a dose-response analysis from the UK biobank.ESC heart failure · 2026Article
- Time to first cigarette after waking and risk of incident chronic respiratory diseases in males: A prospective national cohort study.Tobacco induced diseases · 2026Article
- Association of smoking behavior and time to first cigarette with all-cause and cause-specific mortality: A cohort analysis from the NHANES 2001-2018.Tobacco induced diseases · 2026Article
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9 authors.
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Abstract
aimsAlthough smoking is a well-known risk factor for atrial fibrillation (AF), the association of smoking timing with AF risk remains unclear. This study aimed to prospectively investigate the association of smoking timing with the risk of incident AF and test the modification effect of genetic susceptibility. METHODS AND
resultsA total of 305 627 participants with detailed information for time from waking to the first cigarette were enrolled from UK Biobank database. The Cox proportional hazard model was employed to assess the relationship between smoking timing and AF risk. The weighted genetic risk score for AF was calculated. Over a median 12.2-year follow-up, 13 410 AF cases were documented. Compared with non-smokers, time from waking to the first cigarette showed gradient inverse associations with the risk of incident AF (P-trend <0.001). The adjusted hazard ratio related to smoking timing was 1.13 [95% confidence interval (CI): 0.96-1.34] for >120 min, 1.20 (95% CI: 1.01-1.42) for 61-120 min, 1.34 (95% CI: 1.19-1.51) for 30-60 min, 1.43 (95% CI: 1.26-1.63) for 5-15 min, and 1.49 (95% CI: 1.24-1.63) for <5 min, respectively. Additionally, we found that the increased risk of AF related to shorter time from waking to the first cigarette was strengthened by the genetic susceptibility to AF.
conclusionOur findings suggest gradient inverse association between time from waking to the first cigarette and risk of incident AF, and the association is strengthened by the genetic susceptibility to AF.
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