Evidence map›Paper›PMID 39178066›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2024

CSF Parvalbumin Levels at Multiple Sclerosis Diagnosis Predict Future Worse Cognition, Physical Disability, Fatigue, and Gray Matter Damage.

Stefano Ziccardi, Agnese Tamanti, Claudia Ruggieri, Maddalena Guandalini, Damiano Marastoni, Valentina Camera, Luigi Montibeller, Valentina Mazziotti, Stefania Rossi, Milena Calderone and 4 more

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Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stefano ZiccardiFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0003-0426-7223
Agnese TamantiFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Claudia RuggieriFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Maddalena GuandaliniFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Damiano MarastoniFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0003-0358-9431
Valentina CameraFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0002-4925-9000
Luigi MontibellerFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Valentina MazziottiFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0002-8746-1082
Stefania RossiFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Milena CalderoneFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Francesca Benedetta PizziniFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0002-6285-0989
Stefania MontemezziFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.
Roberta MagliozziFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0001-8284-7763
Massimiliano CalabreseFrom the Department of Neurosciences (S.Z., A.T., C.R., M.G., D.M., V.C., L.M., V.M., S.R., R.M., M. Calabrese), Biomedicine and Movement, University of Verona; Department of Oncology and Molecular Medicine (S.R.), Istituto Superiore di Sanità, Rome; Radiology Unit (M. Calderone), Cmsr Veneto Medica s.r.l., Altavilla Vicentina, Vicenza; and Institute of Radiology (F.B.P., S.M.), University of Verona, Italy.ORCID 0000-0002-3362-7403

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesCognitive impairment (CI) in multiple sclerosis (MS) is frequent and determined by a complex interplay between inflammatory and neurodegenerative processes. We aimed to investigate whether CSF parvalbumin (PVALB), measured at the time of diagnosis, may have a prognostic role in patients with MS.

methodsIn this cohort study, CSF analysis of PVALB and Nf-L levels was performed on all patients at diagnosis (T0) and combined with physical, cognitive, and MRI assessment after an average of 4 years of follow-up (T4) from diagnosis. Cognitive performance was evaluated with a comprehensive neuropsychologic battery: both global (cognitively normal, CN, mildly CI, mCI, and severely CI, sCI) and domain cognitive status (normal/impaired in memory, attention/information processing speed, and executive functions) were considered. Cortical thickness and gray matter volume data were acquired using 3T MRI scanner.

resultsA total of 72 patients with MS were included. At diagnosis, PVALB levels were higher in those patients who showed a worsening physical disability after 4 years of follow-up ( DISCUSSION: The significant association found between parvalbumin levels in the CSF at diagnosis and cognitive, clinical, and neuroradiologic worsening after 4 years of follow-up support the idea that parvalbumin, in addition to Nf-L, might represent a new potential prognostic biomarker, reflecting MS neurodegenerative processes occurring since early disease stages.

Indexed as

Cognitive DysfunctionFatigueGray MatterMultiple SclerosisParvalbuminsAdultBiomarkersCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsBiomarkersneurofilament protein LNeurofilament ProteinsParvalbumins

Identifiers

PMID39178066
PMCPMC11368234

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